{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:09:53Z","timestamp":1790834993184,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study aims to analyze the relationship between chronic periodontitis and C\u2010reactive protein (CRP) by considering associated variables in individuals with or without cardiovascular disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A sample of 359 individuals of both sexes (aged \u226540 years) was assessed. Among these individuals, 144 subjects were admitted to the hospital because of a first occurrence of acute myocardial infarction; 80 subjects were in the hospital for reasons other than acute myocardial infarction; and 135 subjects were living in the community. A questionnaire was applied to obtain demographic and lifestyle characteristics. Complete clinical periodontal examinations and anthropometric assessments were performed. CRP levels, plasma glucose levels, lipid profiles, and blood tests were performed to investigate any conditions that might have suggested infection and\/or inflammation. CRP evaluations were performed using nephelometry. Individuals were considered to have periodontal disease if they simultaneously presented at least four teeth with one or more sites with probing depth \u22654 mm, clinical attachment loss \u22653 mm, and bleeding on probing. Procedures for descriptive analyses and logistic regression were used.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: In the chronic periodontitis group, mean CRP levels were higher than those in the group without chronic periodontitis (2.6 \u00b1 2.6 mg\/L versus 1.78 \u00b1 2.7 mg\/L, respectively). The final model showed that individuals with chronic periodontitis were more likely to have high CRP levels (adjusted odds ratio: 2.26; 95% confidence interval: 1.30 to 3.93) considering the effects of age, schooling level, sex, smoking, high\u2010density lipoprotein cholesterol, and diabetes.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In this study, chronic periodontitis is associated with elevated plasma CRP levels, even after controlling for several potential confounders.<\/jats:p>","DOI":"10.1902\/jop.2010.100511","type":"journal-article","created":{"date-parts":[[2010,12,28]],"date-time":"2010-12-28T19:56:06Z","timestamp":1293566166000},"page":"969-978","source":"Crossref","is-referenced-by-count":94,"title":["Chronic Periodontitis and C\u2010Reactive Protein Levels"],"prefix":"10.1002","volume":"82","author":[{"given":"Isaac Suzart","family":"Gomes\u2010Filho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julita Maria","family":"Freitas Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Seixas","family":"da Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johelle Santana","family":"Passos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Oliveira","family":"Teixeira de Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiara Silva","family":"Arag\u00e3o Farias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruany","family":"Amorim da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Novais","family":"Silva Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Lopes","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio Lima","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01144.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090499"},{"key":"e_1_2_7_4_1","first-page":"425","article-title":"Systemic inflammation in cardiovascular and periodontal disease: Comparative study","volume":"9","author":"Glurich I","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00380-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070150"},{"key":"e_1_2_7_7_1","first-page":"26","article-title":"Acute\u2010phase positive reactive plasmatic proteins (in Portuguese)","volume":"36","author":"Correia CR","year":"2000","journal-title":"J Bras Reumat"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-5-199503010-00003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365519909168322"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00333-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.052"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61717-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.030"},{"key":"e_1_2_7_14_1","unstructured":"American Heart Association.Inflammation heart disease and stroke: The role of C\u2010reactive protein. 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