{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:11:49Z","timestamp":1790460709465,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The proinflammatory chemokine interleukin (IL)\u20108 is important in the regulation of the inflammatory response. Analyses of the single nucleotide polymorphism (SNP) reference sequence (rs) 4073 showed that the A allele upregulated IL\u20108 levels after stimulation with lipopolysaccharides. We investigated the association of the SNP rs4073 with chronic periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Genotyping was performed by a standard polymerase chain reaction\u2013restriction fragment length polymorphism assay in 289 genomic DNA samples of healthy control subjects and patients with chronic periodontitis; analyses were adjusted by multivariate logistic regression modeling. A real\u2010time polymerase chain reaction performance was used to detect levels of the IL\u20108 mRNA.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The analysis pointed to a statistically significant association of chronic periodontitis with the heterozygous TA genotype (<jats:italic>P<\/jats:italic> = 0.001); the results showed an increase in the frequency of the A allele in the diseased group (36% in the control group versus 48% in the periodontitis group). The higher levels of the IL\u20108 mRNA were found in the periodontitis group, mainly in individuals who presented the TA genotype (<jats:italic>P<\/jats:italic> = 0.03).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The SNP rs4073 was associated with chronic periodontitis in non\u2010smoker Brazilian subjects because the frequency of the A allele was higher in the disease group than in the control group, and the TA genotype was associated with increased levels of IL\u20108 mRNA transcripts.<\/jats:p>","DOI":"10.1902\/jop.2010.100513","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T16:26:47Z","timestamp":1290529607000},"page":"893-899","source":"Crossref","is-referenced-by-count":48,"title":["Interleukin\u20108 Gene Promoter Polymorphism (rs4073) May Contribute to Chronic Periodontitis"],"prefix":"10.1002","volume":"82","author":[{"given":"Denise C.","family":"Andia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naila F. 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