{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:10:11Z","timestamp":1765354211115,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The main objective of the present study was to quantify chlorhexidine (CHX) release after the use of CHX\u2010EDTA root surface treatment as a local\u2010delivery antimicrobial vehicle.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty non\u2010smoking patients clinically diagnosed as having moderate\u2010to\u2010severe chronic periodontitis were selected to participate in this study. After cause\u2010related therapy, one site in every patient received defect overfill with CHX gel 2% (20 sites). In addition, twenty contralateral sites received defect fill of CHX gel after 3 minutes of 24% EDTA gel root surface etching (20 sites). Gingival crevicular fluid samples were collected at 1, 3, 7, and 14 days post\u2010therapy.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The CHX\u2010EDTA group showed statistically significantly higher levels of CHX than those of the control group at 1, 3, and 7 days. At 14 days, the CHX\u2010EDTA group showed 0.8 mg\/mL values.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The use of CHX\u2010EDTA root surface treatment as a local\u2010delivery antimicrobial improves CHX substantivity.<\/jats:p>","DOI":"10.1902\/jop.2010.100523","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T16:26:47Z","timestamp":1290529607000},"page":"751-757","source":"Crossref","is-referenced-by-count":7,"title":["Chlorhexidine Controlled\u2010Release Profile After EDTA Root Surface Etching: An In Vivo Study"],"prefix":"10.1002","volume":"82","author":[{"given":"Ahmed Y.","family":"Gamal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radi M.","family":"Kumper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesham 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