{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:31:39Z","timestamp":1777653099045,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["Y2090009"],"award-info":[{"award-number":["Y2090009"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Hereditary gingival fibromatosis (HGF) is a rare benign disorder characterized by progressive overgrowth of gingiva. Although the clinical and histopathologic characteristics of HGF are explicit, the pathogenic mechanism remains unclear. The goal of this article is to describe a three\u2010generation HGF case and discuss the diagnosis, treatment, and inheritance of the disease. The known cellular and molecular features of HGF are also emphasized.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Family and medical histories of the patients were recorded, and a series of preliminary examinations, including clinical, histologic, radiographic, and gene examination, were performed to make a diagnosis and learn about the genetic characteristics. An all\u2010quadrant flap surgery was performed to remove excess gingiva, and orthodontic treatment was undertaken to help tooth eruption. Recent advances were reviewed for further knowledge of genetic, cellular, and molecular features of HGF.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The patient's manifestations and examinations showed a typical HGF characteristic. There was no recurrence after surgery, and the premolars and molars erupted to bite plane. Genetic studies have found several gene mutations involved in HGF. Only the son\u2010of\u2010sevenless\u20101 gene is identified. Multiple molecular factors, such as transforming growth factor\u2010\u03b2 and matrix metalloproteinases, participate in HGF, regulating the extracellular matrix.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Surgical intervention is the usual treatment of HGF, but patients still have to deal with the risk of recurrence. Once the correlations between gene mutations, molecular changes, histology, and clinical situation are clear, they can be applied to clinical application, providing novel methods for disease prognosis and diagnosis and targets for disease prevention and treatment.<\/jats:p>","DOI":"10.1902\/jop.2010.100599","type":"journal-article","created":{"date-parts":[[2010,12,13]],"date-time":"2010-12-13T23:22:45Z","timestamp":1292282565000},"page":"1089-1095","source":"Crossref","is-referenced-by-count":11,"title":["Hereditary Gingival Fibromatosis: A Three\u2010Generation Case and Pathogenic Mechanism Research on Progress of the Disease"],"prefix":"10.1002","volume":"82","author":[{"given":"Jiejun","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xutao","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5005\/jcdp-8-1-90"},{"key":"e_1_2_6_3_1","first-page":"471","article-title":"Gingival fibromatosis (hereditary hyperplastic gingivitis) in a wild European red fox (Vulpes vulpes)","volume":"115","author":"Schulze C","year":"2008","journal-title":"Dtsch Tierarztl Wochenschr"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/339689"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.06.006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2299"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050379"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2008.05.011"},{"key":"e_1_2_6_9_1","first-page":"54","article-title":"Gingival fibromatosis and partial duplication of the short arm of chromosome 2 (dup(2)(p13\u2014>p21))","volume":"39","author":"Fryns JP","year":"1996","journal-title":"Ann Genet"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/301797"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2001.6542"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2005.00488.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-1034-9"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-006-0283-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32034"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01438.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701609200"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600104"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309698200"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01180.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2001.300505.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00928.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.3.296"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01567.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01063.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2007.07.006"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2010.100599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:22:41Z","timestamp":1760869361000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2010.100599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["10.1902\/jop.2010.100599"],"URL":"https:\/\/doi.org\/10.1902\/jop.2010.100599","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}