{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:34:32Z","timestamp":1760920472555,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> We aimed to analyze clinical, microbiologic, and serologic effects of chlorhexidine (CHX) chips used as a subgingival controlled\u2010release delivery device before and immediately after scaling and root planing (SRP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010four patients presenting with \u226512 teeth with probing depth (PD) \u22655 mm and bleeding on probing were assigned in test or control groups. After prophylaxis, CHX chips (test) or placebo chips (control) were placed in pockets with PD \u22655 mm. Ten days later, SRP was performed in all teeth with PD \u22654 mm in a single appointment. Immediately after SRP, new chips were inserted in all pockets with PD \u22655 mm. Parameters were assessed at baseline; beginning of SRP; and 1, 3, and 6 months after treatment. Subgingival samples were obtained at baseline; beginning of SRP; and at 1 month after treatment. Periodontal pathogens <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>, <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Prevotella intermedia<\/jats:italic>, <jats:italic>Tannerella forsythia<\/jats:italic>, and <jats:italic>Treponema denticola<\/jats:italic> were analyzed. Serum levels of high sensitive C\u2010reactive and lipopolysaccharide\u2010binding proteins were measured. The changes of the parameters between and within the groups were tested by Mann\u2010Whitney <jats:italic>U<\/jats:italic> test (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> All clinical and serologic parameters improved in both groups over time. There was a significant difference in clinical attachment level (CAL) gain from baseline to 6 months between groups (1.17 mm in the test group versus 0.79 mm in the placebo group) (<jats:italic>P<\/jats:italic> &lt;0.05). The treatment with CHX chips showed a greater reduction of the microorganisms of the \u201cred complex\u201d after 1 month (<jats:italic>P<\/jats:italic> = 0.02).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The use of CHX chips before and immediately after SRP improved CAL and reduced the subgingival microorganisms of the red complex in the treatment of chronic periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2011.100287","type":"journal-article","created":{"date-parts":[[2011,4,14]],"date-time":"2011-04-14T11:52:35Z","timestamp":1302781955000},"page":"1131-1139","source":"Crossref","is-referenced-by-count":19,"title":["A Novel Approach to the Use of Subgingival Controlled\u2010Release Chlorhexidine Delivery in Chronic Periodontitis: A Randomized Clinical Trial"],"prefix":"10.1002","volume":"82","author":[{"given":"Jose 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