{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:26:48Z","timestamp":1760920008305,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Interleukin (IL)\u201010 is an important cytokine in immune regulation, and the \u22121087 IL\u201010 single nucleotide polymorphism (SNP) is associated with chronic periodontitis. The binding of the transcription factor Sp1 to the \u22121087 position in the IL\u201010 promoter upregulates IL\u201010 gene expression, especially in patients with the GG genotype. A correlation between the \u22121087 GG genotype and high IL\u201010 and Sp1 gene expressions was found.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010five individuals with severe generalized chronic periodontitis were genotyped for the \u22121087 IL\u201010 gene polymorphism. SV40 promoter factor 1\/specificity protein 1 (Sp1) and IL\u201010 mRNA were analyzed using a real\u2010time polymerase chain reaction. The amount of Sp1\u2010positive cells and Sp1\u2010positive B cells, as well as the amount of Sp1 protein, in periodontitis lesions were assessed using immunohistochemistry and an in situ proximity ligation assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The mRNA expression of Sp1 and IL\u201010 in patients with the GG genotype was four times higher than that in patients with the AA genotype. Proportions of Sp1\u2010positive cells overall and Sp1\u2010positive B cells were larger in patients with the GG genotype than in patients with the AA genotype.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The transcription factor Sp1 was present in large amounts in periodontitis lesions, and the local expression of Sp1 was related to the \u22121087 IL\u201010 SNP.<\/jats:p>","DOI":"10.1902\/jop.2011.100623","type":"journal-article","created":{"date-parts":[[2011,2,10]],"date-time":"2011-02-10T21:57:37Z","timestamp":1297375057000},"page":"1376-1382","source":"Crossref","is-referenced-by-count":12,"title":["Interleukin\u201010 Genotypes of the \u22121087 Single Nucleotide Polymorphism Influence Sp1 Expression in Periodontitis Lesions"],"prefix":"10.1002","volume":"82","author":[{"given":"Lena","family":"Larsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Thorbert\u2010Mros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Rymo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tord","family":"Berglundh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00820.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2007.00223.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.6.2081"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70238-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63052-9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00025-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.1996.0393"},{"key":"e_1_2_7_9_1","first-page":"421","article-title":"Spontaneous 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