{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:04:42Z","timestamp":1781103882707,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study compares the levels of cytokines and bone\u2010related factors in the gingival crevicular fluid (GCF) of systemically healthy patients with chronic periodontitis (CP); and better\u2010controlled, and poorly controlled patients with type 2 diabetes and CP.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010seven patients with type 2 diabetes and CP and 20 systemically healthy patients with CP were enrolled in this study. The patients with diabetes mellitus were categorized as better\u2010controlled (n = 17; HbA<jats:sub>1c<\/jats:sub> levels \u22648%) or poorly controlled (n = 20; glycated hemoglobin values &gt;8%). Levels of tumor necrosis factor\u2010\u03b1, interleukin (IL)\u20104, interferon (IFN)\u2010\u03b3, IL\u201023, IL\u201017, soluble receptor activator of nuclear factor\u2010kappa B ligand (sRANKL), and osteoprotegerin (OPG) in GCF of diseased sites were analyzed by enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Type 2 diabetes mellitus, as a whole, upregulates the levels of OPG, sRANKL, IFN\u2010\u03b3, IL\u201017, and IL\u201023 and downregulates the production of IL\u20104 in sites with CP (<jats:italic>P<\/jats:italic> &lt;0.05). Better\u2010controlled individuals exhibited the highest levels of IFN\u2010\u03b3, whereas poorly controlled patients presented the highest levels of IL\u201017 (<jats:italic>P<\/jats:italic> &lt;0.05). There were no differences in the levels of tumor necrosis factor\u2010\u03b1, OPG, and IL\u201023 among systemically healthy, better\u2010controlled, and poorly controlled patients with diabetes (<jats:italic>P<\/jats:italic> &gt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Increased levels of proinflammatory cytokines and RANKL were observed in the GCF of patients with type 2 diabetes with CP, compared to patients without diabetes. In addition, poor or good glycemic status seems to modulate osteo\u2010immunoinflammatory mediators in a different manner.<\/jats:p>","DOI":"10.1902\/jop.2011.100643","type":"journal-article","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T03:13:46Z","timestamp":1296616426000},"page":"1187-1196","source":"Crossref","is-referenced-by-count":95,"title":["Cytokines and Bone\u2010Related Factors in Systemically Healthy Patients With Chronic Periodontitis and Patients With Type 2 Diabetes and Chronic Periodontitis"],"prefix":"10.1002","volume":"82","author":[{"given":"Fernanda","family":"Vieira Ribeiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Cutrim","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa 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