{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:56:34Z","timestamp":1774266994345,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of this study is to compare the additional benefit of systemic antimicrobials versus placebos to a repeated mechanical instrumentation combined with comprehensive local chemical plaque control for the periodontal treatment of generalized aggressive periodontitis (GAgP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This was a 6\u2010month randomized, double\u2010masked, placebo\u2010controlled clinical trial. All GAgP patients received full\u2010mouth disinfection followed by staged scaling and root planing without (placebo group; n = 17) or with (test group; n = 18) systemic antimicrobials (500 mg amoxicillin [AMX] + 250 mg metronidazole [MET]; three times a day for 10 days). Clinical parameters were measured at baseline and 3 and 6 months post\u2010therapy. Significant differences between groups at baseline were sought by using the Mann\u2010Whitney <jats:italic>U<\/jats:italic> test, whereas comparisons over time were examined by using a general linear model repeated measures procedure.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Both groups demonstrated similar improvements in most parameters over time. The test group presented a greater mean probing depth (PD) reduction and clinical attachment level (CAL) gain at sites with initially moderate PD at 6 months (<jats:italic>P<\/jats:italic> &lt;0.03). No differences were seen between groups regarding mean reductions and mean gains, respectively, for PD and CAL initially \u22657 mm. The test group presented a higher percentage of sites that improved \u22652 mm and ended up with PD \u22644 mm or a lower percentage of sites that worsened \u22652 mm and remained with PD &gt;4 mm at 3 months (<jats:italic>P<\/jats:italic> &lt;0.01). No differences were noticed between groups for these parameters at 6 months.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> AMX + MET brought additional clinical effects to the repeated mechanical and antiseptic treatment of GAgP in a very short time (3 months), which tended to fade away over time (6 months).<\/jats:p>","DOI":"10.1902\/jop.2011.100656","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T12:04:06Z","timestamp":1295006646000},"page":"1121-1130","source":"Crossref","is-referenced-by-count":66,"title":["Systemic Antimicrobials Adjunctive to a Repeated Mechanical and Antiseptic Therapy for Aggressive Periodontitis: A 6\u2010Month Randomized Controlled Trial"],"prefix":"10.1002","volume":"82","author":[{"given":"Victor M.","family":"Varela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora","family":"Heller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra X.","family":"Silva\u2010Senem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cyn\u00e9sia M. 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