{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:41:07Z","timestamp":1789594867988,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The standard of care for increasing keratinized gingiva adjacent to teeth that do not require root coverage is the free gingival graft (FGG). A pilot study indicated that the use of a living cellular construct (LCC) could be effective in this clinical scenario.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A pivotal, multicenter, randomized, within\u2010patient, controlled, open\u2010label trial was conducted (N = 96 patients). After removing the mucosa and keratinized gingiva from the test site, either an LCC or FGG was applied. The primary efficacy endpoint was the ability of the LCC to regenerate \u22652 mm keratinized gingiva at 6 months. Secondary measures were the same color and texture as the adjacent tissue, a 1\u2010mm width of keratinized gingiva at 6 months, patient treatment preference, surgical site sensitivity at 1 week, and patient\u2010reported pain after 3 days. Safety was assessed by reports of adverse events.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At 6 months, the LCC regenerated \u22652 mm of keratinized gingiva in 95.3% of patients (81 of 85 patients; <jats:italic>P<\/jats:italic> &lt;0.001 versus a 50% predefined standard). As expected, the FGG generated more keratinized gingiva than the LCC (4.57 \u00b1 1.0 mm versus 3.2 \u00b1 1.1 mm, respectively). The gingiva regenerated with the LCC matched the color and texture of the adjacent gingiva. All patients achieved \u22651 mm keratinized gingiva with the LCC treatment by 6 months, and more patients preferred treatment with the LCC than with the FGG. No difference in sensitivity or pain was noted between the treatments. The treatments were well tolerated, and reported adverse events were typical for this type of periodontal surgery.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The use of an LCC may provide a safe and effective therapy for augmenting the zone of keratinized gingiva.<\/jats:p>","DOI":"10.1902\/jop.2011.100671","type":"journal-article","created":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T03:31:27Z","timestamp":1301369487000},"page":"1414-1423","source":"Crossref","is-referenced-by-count":59,"title":["Living Cellular Construct for Increasing the Width of Keratinized Gingiva: Results From a Randomized, Within\u2010Patient, Controlled Trial"],"prefix":"10.1002","volume":"82","author":[{"given":"Michael K.","family":"McGuire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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