{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:55:29Z","timestamp":1769828129412,"version":"3.49.0"},"reference-count":62,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of the present study is to verify a possible association between herpesviruses and periodontal pathogens in individuals with human immunodeficiency virus (HIV) and periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010seven patients with HIV and chronic periodontitis and 23 patients with HIV and gingivitis were included in the study. Probing depth, clinical attachment loss, gingival index, and plaque index were recorded. Blood, saliva, and subgingival plaque were processed for viral and bacterial identification. Bacteria were identified by 16S rRNA\u2010based polymerase chain reaction and viruses by the nested polymerase chain reaction.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> For the chronic periodontitis group, Epstein\u2010Barr (EBV)\u20101 (70.4%) and <jats:italic>Tannerella forsythia<\/jats:italic> (<jats:italic>Tf<\/jats:italic>) (51.8%) presented higher detection in subgingival plaque and saliva (81.5% and 40.7%, respectively) than in blood (22% and 0%, respectively) (<jats:italic>P<\/jats:italic> &lt;0.005 and <jats:italic>P<\/jats:italic> &lt;0.0001, respectively). <jats:italic>Porphyromonas gingivalis (Pg)<\/jats:italic> was more frequent in subgingival plaque (77.7%; <jats:italic>P<\/jats:italic> &lt;0.0001). In the gingivitis group, <jats:italic>Pg<\/jats:italic> and human cytomegalovirus (HCMV) presented higher frequency in subgingival plaque (95.6% and 91.3%, respectively; <jats:italic>P<\/jats:italic> &lt;0.0001 and <jats:italic>P<\/jats:italic> = 0.004). <jats:italic>Tf<\/jats:italic> and EBV\u20101 were detected more frequently in subgingival plaque (47.8% and 78.3%, respectively) and saliva (52.2% and 52.2%, respectively; <jats:italic>P<\/jats:italic> = 0.004 and <jats:italic>P<\/jats:italic> &lt;0.005) than in blood. EBV\u20101, EBV\u20101\u2013HCMV, and presence of different viruses presented an association with periodontitis in saliva.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> No association was detected for herpesviruses and periodontal pathogens in patients who are HIV\u2010positive with periodontitis. EBV\u20101 and coinfection (EBV\u20101\u2013HCMV) were associated with patients who are HIV\u2010positive with periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2011.100723","type":"journal-article","created":{"date-parts":[[2011,5,12]],"date-time":"2011-05-12T17:45:49Z","timestamp":1305222349000},"page":"1442-1452","source":"Crossref","is-referenced-by-count":18,"title":["Relationship Between Herpesviruses and Periodontopathogens in Patients With HIV and Periodontitis"],"prefix":"10.1002","volume":"82","author":[{"given":"Sabrina R.","family":"Grande","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana V.","family":"Imbronito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osmar S.","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio M.","family":"Pannuti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio D.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz A.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110580"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(00)88892-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00728.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00659.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.2002.170606.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.5.478"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21180"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070388"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.2003.00053.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.62"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923970009026002"},{"key":"e_1_2_7_13_1","first-page":"179","article-title":"Absorption of viruses into oral lymphocytes and decreased antibacterial activity of oral polymorphonuclear leukocytes","volume":"31","author":"Ongr\u00e1di J","year":"1984","journal-title":"Acta Microbiol Hung"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.2.326"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2000.035001003.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1993.tb01074.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1998.tb01916.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-71-1-97"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.4049\/jimmunol.147.2.685","article-title":"Productive infection of CD4+ and CD8+ mature human T cell populations and clones by human herpesvirus 6. Transcriptional down\u2010regulation of CD3","volume":"147","author":"Lusso P","year":"1991","journal-title":"J Immunol"},{"key":"e_1_2_7_20_1","first-page":"3","article-title":"Herpesviruses and AIDS","volume":"100","author":"Griffiths PD","year":"1996","journal-title":"Scand J Infect Dis Suppl"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70352-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2001.280115.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01307.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.1.74"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2000.035005278.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028004311.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00317.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00806.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.2003.00064.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1991.tb00449.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.1.48"},{"key":"e_1_2_7_32_1","unstructured":"Centers for Disease Control and 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults prevention. Available at:http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/00018871.htm. Accessed January 15 2011."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01034.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2006.02.007"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.28.3.495-503.1990"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(87)90039-4"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.11.3028-3030.1995"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-72-8-1985"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1996.tb00180.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1139\/W08-006"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.01043.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01123.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00414.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00374-07"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-008-0186-7"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1999.tb02025.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1086\/378808"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00256-06"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21214"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2004.00144.x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2005.00790.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1086\/322630"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.P04039"},{"key":"e_1_2_7_55_1","first-page":"89","article-title":"Periodontal conditions and distribution of Prevotella intermedia, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in HIV\u2010infected patients undergoing anti\u2010retroviral therapy and in an HIV\u2010seronegative group of the Venezuelan population","volume":"21","author":"Brito A","year":"2008","journal-title":"Acta Odontol Latinoam"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1997.tb00350.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.1.33"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1086\/343739"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb00423.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/24.5.836"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.35.6.1600-1603.1997"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.6.915"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200205030-00005"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2011.100723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:32:28Z","timestamp":1760869948000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2011.100723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1902\/jop.2011.100723"],"URL":"https:\/\/doi.org\/10.1902\/jop.2011.100723","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}