{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:59:34Z","timestamp":1771016374126,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Titanium implants are widely used in dentistry to replace lost teeth. Various surface modifications have been used to improve implant retention and osseointegration. This study is designed to compare the ability of three titanium surfaces to promote cell attachment and cell motility of cells relevant to periodontal tissues.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Three clinically relevant surfaces were tested: 1) machined titanium; 2) a titanium surface roughened through acid etching (dual thermal\u2010etched titanium [DTET]); and 3) a titanium surface roughened with nanometer\u2010scale calcium phosphate deposition (nanoscale calcium phosphate\u2013impregnated titanium [NCPIT]). Cell attachment and migration were examined for four cell types: rat osteosarcoma cells, human osteoblasts, and gingival and periodontal ligament (PDL) fibroblasts.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> All four cell types attached to each of the three titanium surfaces equally by 2 hours, and the PDL and gingival fibroblasts generally displayed less attachment than the osteosarcoma cells and osteoblasts. The cells displayed differential motility and long\u2010term attachment to each of the titanium surfaces. Osteosarcoma cells displayed preferential motility on NCPIT, whereas PDL fibroblasts were more motile on machined titanium, and gingival fibroblasts moved more rapidly on both DTET and NCPIT. Osteoblasts displayed little motility on any of the titanium surfaces and lost viability on NCPIT after 24 hours. Gingival fibroblasts lost attachment to machined titanium.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Periodontal cells displayed differential motility and long\u2010term attachment to titanium surfaces. Selective modification of titanium surface properties in various regions of an implant may be useful in guiding specific cell populations to specific locations where they might best aid in osseointegration and soft tissue remodeling.<\/jats:p>","DOI":"10.1902\/jop.2011.100733","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T20:41:40Z","timestamp":1302640900000},"page":"90-100","source":"Crossref","is-referenced-by-count":8,"title":["Altered Cell Motility and Attachment With Titanium Surface Modifications"],"prefix":"10.1002","volume":"83","author":[{"given":"Archontia","family":"Palaiologou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Stoute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Lallier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"537","article-title":"The initial attachment and subsequent behavior of osteoblastic cells and oral epithelial cells on titanium","volume":"14","author":"Goto T","year":"2004","journal-title":"Biomed Mater Eng"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10\u2010year period","volume":"16","author":"Br\u00e5nemark PI","year":"1977","journal-title":"Scand J Plast Reconstr Surg Suppl"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30009"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018558816871"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.2798042"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2010.02.050"},{"key":"e_1_2_7_8_1","first-page":"63","article-title":"On implant surfaces: A review of current knowledge and opinions","volume":"25","author":"Wennerberg A","year":"2010","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01775.x"},{"key":"e_1_2_7_10_1","first-page":"1078","volume-title":"Carranza's Clinical Periodontology","author":"Newman MG","year":"2006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01086.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00298617"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(80)90097-7"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1998.tb00121.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.20003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.20021"},{"key":"e_1_2_7_17_1","first-page":"391","article-title":"Mechanisms of endosseous integration","volume":"11","author":"Davies JE","year":"1998","journal-title":"Int J Prosthodont"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2010.01913.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2008.00128.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2009.00147.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01363.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0NR00485E"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.05.012"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.7.1044"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.6.798"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650100203"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800081301"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-006-0372-4"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408300904"},{"key":"e_1_2_7_30_1","first-page":"627","article-title":"Bone cell attachment to dental implants of different surface characteristics","volume":"16","author":"Lumbikanonda N","year":"2001","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20622"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31040"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v006a03"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.268.5.C1090"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650010404"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611781200"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02555114"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v019a22"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.10.1743"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2009.01.095"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.22203\/eCM.v004a01"},{"key":"e_1_2_7_42_1","first-page":"193","article-title":"A prospective multicenter clinical study of the Osseotite implant: Four\u2010year interim report","volume":"16","author":"Testori T","year":"2001","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01427.x"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2011.100733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:08:01Z","timestamp":1760879281000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2011.100733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1902\/jop.2011.100733"],"URL":"https:\/\/doi.org\/10.1902\/jop.2011.100733","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}