{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:41:54Z","timestamp":1791276114854,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009504","name":"University of Missouri-Kansas City","doi-asserted-by":"publisher","award":["0903"],"award-info":[{"award-number":["0903"]}],"id":[{"id":"10.13039\/100009504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    It was previously reported that dentin matrix protein 1\u2013null mice, which are the hypophosphatemic rickets animal model, postnatally developed severe periodontal defects. However, to the best of our knowledge, it was not documented whether similar periodontal defects were present in human patients with hypophosphatemic rickets. The aim of this study is to evaluate the periodontal status of adult patients with hypophosphatemic rickets.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    This case\u2010series study evaluates the periodontal condition of adults with genetic hypophosphatemic rickets and compared their periodontal status with similar data from several cycles of the National Health and Nutrition Examination Survey (NHANES). Information regarding medical histories, dental histories, intraoral photos, probing depths (PD), calculated clinical attachment loss (AL), the presence of gingival recession, bleeding on probing, and full\u2010mouth radiographic surveys were acquired. Descriptive statistics were used for comparison to NHANES data.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    A total of 10 adult patients with hypophosphatemic rickets (two males and eight females) were evaluated. The definition of periodontitis used in this study is as follows: \u201cA periodontitis case was defined as a person who had \u2265 3 sites with clinical AL \u2265 4 mm and \u2265 2 sites with PD \u2265 3 mm.\u201d According to this definition, the patients exhibited periodontal bone loss at a much higher prevalence (60%) compared to the reported national periodontitis prevalence (3.6% to 7.3%).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The preliminary data from our study suggests that patients with hypophosphatemic rickets are more prone to periodontal bone loss than the general population and may require a more careful examination by dental care providers.\n                  <\/jats:p>","DOI":"10.1902\/jop.2011.100736","type":"journal-article","created":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T11:25:41Z","timestamp":1300706741000},"page":"1530-1535","source":"Crossref","is-referenced-by-count":23,"title":["Periodontal Status of Patients With Hypophosphatemic Rickets: A Case Series"],"prefix":"10.1002","volume":"82","author":[{"given":"Ling","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruohong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri S.","family":"Alon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles M.","family":"Cobb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095-130"},{"key":"e_1_2_6_3_1","first-page":"342","volume-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","author":"Alon US","year":"2006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/81664"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1868"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1905"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263X.1998.00059.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.107522"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004770-200404000-00015"},{"key":"e_1_2_6_10_1","first-page":"61","article-title":"Prevalence and pathogenesis of dental and periodontal lesions in children with X\u2010linked hypophosphatemic rickets","volume":"7","author":"Baroncelli GI","year":"2006","journal-title":"Eur J Paediatr Dent"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700708"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00742.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510377793"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401010"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2007.00406.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.09.016"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-010-0169-0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.5.360"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0261"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2011.100736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:07:46Z","timestamp":1760879266000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2011.100736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["10.1902\/jop.2011.100736"],"URL":"https:\/\/doi.org\/10.1902\/jop.2011.100736","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}