{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:17:52Z","timestamp":1773886672537,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T00:00:00Z","timestamp":1338508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21792110"],"award-info":[{"award-number":["21792110"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21390553"],"award-info":[{"award-number":["21390553"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of this study is to examine the relationship between salivary LL\u201037 levels and clinical severity in patients with chronic periodontitis (CP). The presence\/absence of four periodontopathic bacteria and salivary cotinine levels were also examined to assess the impact of these factors on LL\u201037 production.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Unstimulated salivary samples were collected from 69 patients with CP. Salivary concentrations of LL\u201037 and cotinine were measured by enzyme\u2010linked immunosorbent assay. <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>, <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Tannerella forsythia<\/jats:italic>, and <jats:italic>Treponema denticola<\/jats:italic> in saliva were detected by polymerase chain reaction. Periodontal examination included determination of probing depth (PD), clinical attachment level, bleeding on probing, and plaque control record.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Mean salivary LL\u201037 concentration was 225.0 \u00b1 227.2 ng\/mL, and a high prevalence of periodontopathic bacteria was observed. The stepwise ordinal logistic regression model showed that high salivary LL\u201037 levels were significantly associated with the presence of <jats:italic>T. denticola<\/jats:italic> and higher percentage of teeth with PD \u22655 mm. In addition, higher salivary cotinine levels (\u22658 ng\/mL) were negatively associated with salivary LL\u201037 levels.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Salivary LL\u201037 level was positively correlated with severe periodontal destruction, and production was apparently associated with periodontopathic bacterial infection. The negative correlations between salivary LL\u201037 and cotinine levels also suggest that smoking or long\u2010term exposure to environmental tobacco smoke can lead to lower LL\u201037 levels in the oral cavity and increased risk of periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2011.100767","type":"journal-article","created":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T13:42:03Z","timestamp":1317044523000},"page":"766-772","source":"Crossref","is-referenced-by-count":31,"title":["Salivary Levels of Antibacterial Peptide (LL\u201037\/hCAP\u201018) and Cotinine in Patients With Chronic 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