{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:59:00Z","timestamp":1791212340369,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Platelet\u2010rich fibrin (PRF) is considered a second\u2010generation platelet concentrate that is widely used in osseous regeneration. The present study aims to explore the clinical and radiographic effectiveness of autologous PRF in the treatment of intrabony defects in patients with chronic periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Fifty\u2010six intrabony defects were treated with either autologous PRF with open\u2010flap debridement or open\u2010flap debridement alone. Clinical parameters such as the probing depth (PD) and periodontal attachment level (PAL) were recorded at baseline and 9 months postoperatively. The defect fill at baseline and 9 months was calculated on standardized radiographs by using image\u2010analysis software.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The mean PD reduction was greater in the test group (4.55 \u00b1 1.87 mm) than in the control group (3.21 \u00b1 1.64 mm), whereas the mean PAL gain was also greater in the test group (3.31 \u00b1 1.76) compared to the control group (2.77 \u00b1 1.44 mm). Furthermore, a significantly greater percentage of mean bone fill was found in the test group (48.26% \u00b1 5.72%) compared to the control group (1.80% \u00b1 1.56%).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Within the limits of the present study, there was greater PD reduction, PAL gain, and bone fill at sites treated with PRF with conventional open\u2010flap debridement compared to conventional open\u2010flap debridement alone. However, a long\u2010term, multicentered randomized controlled clinical trial is required to know the clinical and radiographic effects of PRF on bone regeneration.<\/jats:p>","DOI":"10.1902\/jop.2011.110075","type":"journal-article","created":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T20:59:26Z","timestamp":1302037166000},"page":"1705-1712","source":"Crossref","is-referenced-by-count":158,"title":["Treatment of 3\u2010Wall Intrabony Defects in Patients With Chronic Periodontitis With Autologous Platelet\u2010Rich Fibrin: A Randomized Controlled Clinical Trial"],"prefix":"10.1002","volume":"82","author":[{"given":"Anuj","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.R.","family":"Pradeep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00157.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00156.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080214"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090058"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100144"},{"key":"e_1_2_7_8_1","first-page":"173","article-title":"Comparison of clinical outcomes 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