{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T18:26:24Z","timestamp":1766427984939,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The periodontal status and effects of non\u2010surgical periodontal treatment in patients with type 2 diabetes mellitus and periodontal disease are assessed.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> One\u2010hundred patients with type 2 diabetes (mean \u00b1 SD hemoglobin (Hb)A1c level: 7.3% \u00b1 0.94%) and periodontal disease were recruited for this study. The group with moderate\u2010to\u2010severe periodontal disease included patients with &gt;1 tooth with a probing depth (PD) \u22655 mm and &gt;2 teeth with a clinical attachment loss (AL) \u22656mm, and the group with mild periodontal disease included patients with &lt;1 affected tooth, and &gt;2 affected with a clinical AL \u22656mm. Patients (28 patients in the mild group and 72 patients in the moderate\u2010to\u2010severe group) underwent non\u2010surgical periodontal treatments. We analyzed differences in serum concentrations of metabolic parameters (glycated hemoglobin and low\u2010density lipoprotein), inflammatory parameters (interleukin [IL]\u20101\u03b2 and C\u2010reactive protein [CRP]), and periodontal parameters between the two groups before treatment and at 3, 6, 9, and 12 months post\u2010therapy.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Seventy\u2010five patients with diabetes (21 patients in the mild group and 54 patients in the moderate\u2010to\u2010severe group) completed the study. Significant differences in the plaque index (PI), gingival index (GI), PD, and clinical AL at examination times were observed in the whole cohort (<jats:italic>P<\/jats:italic> &lt;0.05). We observed significant differences in the PI, GI, and PD in the moderate\u2010to\u2010severe group (<jats:italic>P<\/jats:italic> &lt;0.05), whereas there was only a significant difference in PD in the mild group (<jats:italic>P<\/jats:italic> &lt;0.05) between baseline and 12 months post\u2010treatment. Both groups experienced improved glycemic control, but the difference was insignificant. CRP and IL\u20101\u03b2 levels were significantly different at examination times for the whole cohort (<jats:italic>P<\/jats:italic> &lt;0.05). No significant positive association among metabolic and inflammatory parameters at 12 months post\u2010therapy were found.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Non\u2010surgical periodontal treatment improved and maintained the periodontal health of patients with well\u2010controlled diabetes, but no significant reduction of metabolic parameters was observed over a 1\u2010year period.<\/jats:p>","DOI":"10.1902\/jop.2011.110133","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T11:13:59Z","timestamp":1308654839000},"page":"621-628","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of Periodontal Status and Effectiveness of Non\u2010Surgical Treatment in Patients With Type 2 Diabetes Mellitus in Taiwan for a 1\u2010Year 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