{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:42:36Z","timestamp":1790023356025,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The objective of this case series is to compare root defect coverage results and healing responses of bilateral recession defects treated with acellular dermal matrix (ADM) with and without recombinant human platelet\u2010derived growth factor (rhPDGF).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Seventeen patients with 40 bilateral gingival recession defects were compared. Each defect was \u22652 mm and treated with ADM and a coronally advanced flap. Using split\u2010mouth design, the control\u2010side ADM was hydrated in sterile saline, whereas the test\u2010side ADM was hydrated in rhPDGF. The patients were evaluated at 1 week, 1 month, 3 months, and 6 months. Standardized measurements were taken preoperatively at 3 and 6 months. Healing was clinically assessed at 1 week and 1 month post\u2010surgically.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Both test and control groups showed significant gain in root defect coverage over the 6\u2010month period for all individuals, with the test group showing a 69.0% gain and the control group showing a 76.7% gain. Patients divided into Miller Class I and Class III defects were also found to have a significant gain in root defect coverage over 6 months. The test group showed 84.1% gain, and the control group showed 84.7% gain for Miller Class I defects. For Miller Class III defects, the test group showed 51.5% gain, and the control group showed a 60.8% gain. One week after surgery, 35% of the test group showed better healing, whereas 15% of the control group showed better healing. One month after surgery, 20% of the test group showed better healing, whereas 15% of the control group showed better healing.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Based on the results of this case series, there were no statistically or clinically significant differences in root defect coverage, keratinized tissue, clinical attachment level, or clinical healing for treatment of root recession with a coronally advanced flap and ADM with and without rhPDGF.<\/jats:p>","DOI":"10.1902\/jop.2011.110144","type":"journal-article","created":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T16:33:12Z","timestamp":1323361992000},"page":"893-901","source":"Crossref","is-referenced-by-count":26,"title":["A Comparative Study of Root Defect Coverage Using an Acellular Dermal Matrix With and Without a Recombinant Human Platelet\u2010Derived Growth Factor"],"prefix":"10.1002","volume":"83","author":[{"given":"Christopher M.","family":"Carney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Rossmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Kerns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisha J.","family":"Cipher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry D.","family":"Rees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Rivera\u2010Hidalgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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