{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:24:48Z","timestamp":1780046688401,"version":"3.53.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this investigation is to evaluate clinical and histologic outcome of using medical\u2010grade calcium sulfate hemihydrate (MGCSH) mixed with platelet\u2010rich plasma (PRP) for extraction socket preservation graft before implant placement.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This study is a single\u2010site, randomized and controlled investigation. Sixteen patients with a non\u2010restorable tooth requiring extraction followed by implant placement were enrolled in this study. After extraction of a tooth, eight selected patients randomly received MGCSH mixed with PRP in the extraction sockets (test group), and eight selected patients randomly received collagen resorbable plug dressing material (control group). At the time of extraction and 3 months later (at implant placement surgery), vertical and horizontal socket dimensions were measured. Bone core samples were retrieved from the center of the healed socket before implant placement for histomorphometric analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There was a statistically significant difference between the two groups based on histomorphometric analysis (<jats:italic>P<\/jats:italic> &lt;0.05). New vital bone percentage regenerated after 3 months of healing was 66.5% \u00b1 10.4% in sockets grafted with MGCSH mixed with PRP compared to 38.3% \u00b1 9.3% collagen resorbable plug. There was no statistically significant difference in the amount of vertical and horizontal bone resorption (<jats:italic>P<\/jats:italic> &gt;0.05) between groups. In all cases but two in the control group, implants were placed with primary stability.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> MGCSH mixed with PRP showed greater vital bone volume at 3 months with rapid enhancement of bone healing compared to PRP\u2010free collagen resorbable graft.<\/jats:p>","DOI":"10.1902\/jop.2011.110237","type":"journal-article","created":{"date-parts":[[2011,8,23]],"date-time":"2011-08-23T12:30:27Z","timestamp":1314102627000},"page":"401-409","source":"Crossref","is-referenced-by-count":63,"title":["Extraction Socket Preservation Graft Before Implant Placement With Calcium Sulfate Hemihydrate and Platelet\u2010Rich Plasma: A Clinical and Histomorphometric Study in Humans"],"prefix":"10.1002","volume":"83","author":[{"given":"Ahmad","family":"Kutkut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Andreana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong\u2010ll","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Edward","family":"Monaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"313","article-title":"Bone healing and soft tissue contour changes following single\u2010tooth extraction: A clinical and radiographic 12\u2010month prospective study","volume":"23","author":"Schropp L","year":"2003","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3913(60)90083-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.1969.tb06001.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01209.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01482.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.9.1044"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.110035"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.7.990"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.6.563"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1563\/1548-1336(2001)027<0187:ESRFAR>2.3.CO;2"},{"key":"e_1_2_7_12_1","first-page":"646","article-title":"Socket preservation as a precursor of future implant placement: Review of the literature and case reports","volume":"28","author":"John V","year":"2007","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_13_1","first-page":"614","article-title":"Ridge preservation and augmentation using regenerative materials to enhance implant predictability and esthetics","volume":"28","author":"Keith JD","year":"2007","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_14_1","first-page":"469","article-title":"Preservation of the postextraction alveolar ridge: A clinical and histologic study","volume":"28","author":"Cardaropoli D","year":"2008","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01575.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01305.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070502"},{"key":"e_1_2_7_18_1","first-page":"523","article-title":"Simple preservation of a maxillary extraction socket using beta\u2010tricalcium phosphate with type I collagen: Preliminary clinical and histomorphometric observations","volume":"74","author":"Brkovic BM","year":"2008","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_7_19_1","first-page":"146","article-title":"Socket grafting and alveolar ridge preservation","volume":"27","author":"Misch CE","year":"2008","journal-title":"Dent Today"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070628"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.6.902"},{"key":"e_1_2_7_22_1","first-page":"636","article-title":"Medial\u2010grade calcium sulfate hemihydrate (surgiplaster) in healing of a human extraction socket \u2014 Histologic observation at 3 months: A case report","volume":"20","author":"Guarnieri R","year":"2005","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200301000-00033"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-200101000-00008"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.id.0000136914.82891.20"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080400"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31269"},{"key":"e_1_2_7_28_1","first-page":"93","article-title":"Is platelet\u2010rich plasma the perfect enhancement factor? A current review","volume":"18","author":"S\u00e1nchez AR","year":"2003","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2003.12.003"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.05.055"},{"key":"e_1_2_7_31_1","first-page":"664","article-title":"Platelet\u2010rich plasma: A promising innovation in dentistry","volume":"69","author":"T\u00f6z\u00fcm TF","year":"2003","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2003.08.021"},{"key":"e_1_2_7_33_1","first-page":"15","article-title":"Influence of platelet\u2010rich plasma on osseous healing of dental implants: A histologic and histomorphometric study in minipigs","volume":"18","author":"Zechner W","year":"2003","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1089\/107632702320934092"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-5-13"},{"key":"e_1_2_7_36_1","first-page":"260","article-title":"Ridge preservation techniques for implant therapy","volume":"24","author":"Darby I","year":"2009","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060048"},{"key":"e_1_2_7_38_1","first-page":"529","article-title":"Plasma rich in growth factors: Preliminary results of use in the preparation of future sites for implants","volume":"14","author":"Anitua E","year":"1999","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2007.01827.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00366.x"},{"key":"e_1_2_7_41_1","first-page":"99","article-title":"A simplified socket classification and repair technique","volume":"19","author":"Elian N","year":"2007","journal-title":"Pract Proced Aesthet Dent"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.3.141"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb02129.x"},{"key":"e_1_2_7_44_1","first-page":"902","article-title":"Clinical and histologic healing of human extraction sockets filled with calcium sulfate","volume":"24","author":"Aimetti M","year":"2009","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.3.236"},{"key":"e_1_2_7_46_1","first-page":"656","article-title":"Alveolar ridge preservation prior to implant placement with surgical\u2010grade calcium sulfate and platelet\u2010rich plasma: A pilot study in a canine model","volume":"22","author":"Shi B","year":"2007","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(64)90372-X"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2011.110237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:21:25Z","timestamp":1760869285000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2011.110237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["10.1902\/jop.2011.110237"],"URL":"https:\/\/doi.org\/10.1902\/jop.2011.110237","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}