{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:36:29Z","timestamp":1791822989156,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> There is an ongoing controversy on the benefits of treatment protocols, including dental lasers and photodynamic therapy (PDT). The purpose of this study is to compare the local biologic effects of PDT, diode soft laser (DSL) therapy, and conventional deep scaling and root planing (SRP) in residual pockets.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010two individuals were included based on a history of previous treatment for periodontitis and the persistence of sites with probing depths &gt;4 mm and bleeding on probing. Residual pockets were debrided with an ultrasonic device and then randomly assigned either to PDT, DSL, or SRP. Gingival crevicular fluid was collected before treatment, after 14 days, and at 2 and 6 months. Levels of 13 cytokines and nine acute\u2010phase proteins were measured using a bead\u2010based multiplexing analysis system.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Treatment with PDT, DSL, or SRP led to significant changes in several cytokines and acute\u2010phase proteins: Compared with baseline, levels of interleukin\u201017, basic fibroblast growth factor, granulocyte colony\u2010stimulating factor, granulocyte macrophage colony\u2010stimulating factor, and macrophage inflammatory protein 1\u2010\u03b1 were lower 14 days and 2 months after treatment. Except for granulocyte colony\u2010stimulating factor, these differences remained significant throughout the observation period. The levels of five acute\u2010phase proteins (\u03b1\u20102 macroglobulin, haptoglobin, serum amyloid P, procalcitonin, and tissue plasminogen activator) were significantly higher at 6 months than at baseline. No significant differences were observed among the three treatment modalities at any time point for any biochemical parameter.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Levels of several cytokines and acute\u2010phase proteins significantly changed after treatment regardless of treatment modality. There was no evidence for a specific DSL\u2010 or PDT\u2010enhanced expression of inflammatory mediators.<\/jats:p>","DOI":"10.1902\/jop.2011.110281","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T13:18:19Z","timestamp":1324300699000},"page":"1018-1027","source":"Crossref","is-referenced-by-count":84,"title":["Effect of Photodynamic Therapy, Diode Laser, and Deep Scaling on Cytokine and Acute\u2010Phase Protein Levels in Gingival Crevicular Fluid of Residual Periodontal Pockets"],"prefix":"10.1002","volume":"83","author":[{"given":"Catherine","family":"Giannopoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Cappuyns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Cancela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Cionca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mombelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2001.280102.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02422.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb00104.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.12.750"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02024.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01309.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.1997.tb00254.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-5712(92)90043-C"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.1991.tb00214.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.7.421"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(94)90197-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027009690.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.10.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.3.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2004.03679.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00738.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00283.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1998)22:5<302::AID-LSM7>3.0.CO;2-T"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/clm.1997.15.33"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-007-0513-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.8.1275"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2010.00346.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1993.tb00663.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01259.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080197"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090285"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01670.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01671.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2230103.x"},{"key":"e_1_2_7_31_1","article-title":"Treatment of residual pockets with photodynamic therapy, diode laser or deep scaling. 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