{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:01:50Z","timestamp":1790550110980,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["500311\/2010\u20102"],"award-info":[{"award-number":["500311\/2010\u20102"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["551818\/2010\u20107"],"award-info":[{"award-number":["551818\/2010\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study is to evaluate the gene expression of immune\u2010inflammatory markers in gingival biopsies of patients with type 2 diabetes with chronic periodontitis (CP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Gingival biopsies were harvested from systemically and periodontally healthy patients (SPH), systemically healthy patients with CP (SHCP), and patients with better\u2010controlled and poorly controlled diabetes and CP. The levels of mRNA of interleukin (IL)\u201017, IL\u20106, IL\u201023, IL\u201010, IL\u20104, interferon\u2010\u03b3, toll\u2010like receptor (TLR)\u20102, TLR\u20104, osteoprotegerin, receptor activator of nuclear factor\u2010kappa B ligand (RANKL), tumor necrosis factor\u2010\u03b1, transforming growth factor\u2010\u03b2, transcription factor forkhead box p3, transcription factor orphan nuclear receptor C2 (RORC2), and receptor of advanced glycation end products (RAGE) were evaluated by quantitative real\u2010time polymerase chain reaction.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> All CP groups presented higher levels of mRNA of TLR\u20102, TLR\u20104, IL\u201017, RANKL, and RAGE and a higher frequency of IL\u201017 and TLR\u20102 mRNA\u2010positive biopsies when compared to SPH (<jats:italic>P<\/jats:italic> &lt;0.05). There was a higher frequency of detection of RORC2 in the biopsies from both groups with diabetes compared to the other groups (<jats:italic>P<\/jats:italic> &lt;0.05). The frequency of IL\u20104 mRNA\u2010positive tissues was lower in patients with diabetes compared to SHCP (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> CP, but not type 2 diabetes mellitus, significantly affected the expressions of the evaluated genes related to the innate and adaptive immune responses.<\/jats:p>","DOI":"10.1902\/jop.2011.110324","type":"journal-article","created":{"date-parts":[[2011,8,22]],"date-time":"2011-08-22T13:21:26Z","timestamp":1314019286000},"page":"426-434","source":"Crossref","is-referenced-by-count":53,"title":["Expression of Immune\u2010Inflammatory Markers in Sites of Chronic Periodontitis in Patients With Type 2 Diabetes"],"prefix":"10.1002","volume":"83","author":[{"given":"Poliana Mendes","family":"Duarte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamires","family":"Szeremeske 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