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Plaque, gingivitis, bleeding on probing, suppuration, probing depth, and clinical attachment level were measured at all teeth present. Subgingival biofilm samples from each tooth were analyzed for levels of 40 bacterial species using checkerboard DNA\u2013DNA hybridization. Serum levels of interleukin\u20106 (IL\u20106), tumor necrosis factor\u2010\u03b1, adiponectin, leptin, resistin, and vitamin D were measured at baseline. Sample collection was then performed in a subset of the population 6 months after therapy (n = 17). Serum samples were analyzed using enzyme\u2010linked immunosorbent assay and immunoassays. Differences in clinical, microbial, and serum factors among groups were sought using the Mann\u2010Whitney <jats:italic>U<\/jats:italic> test. Correlations among factors were evaluated using regression analysis. Effects of therapy were sought using the Wilcoxon signed rank test.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There were positive correlations between adiponectin\/vitamin D and between IL\u20106\/leptin, negative correlations between IL\u20106\/vitamin D and leptin\/vitamin D, but no associations between serum analytes and clinical or microbial parameters. Sex and body mass index were associated with levels of adipokines. Periodontal therapy improved clinical and microbiologic parameters but did not influence the levels of serum analytes.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Adipokines and IL\u20106 levels were affected by sex and body mass index. Serum analytes were not influenced by periodontal therapy.<\/jats:p>","DOI":"10.1902\/jop.2011.110346","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T13:18:19Z","timestamp":1324300699000},"page":"1183-1191","source":"Crossref","is-referenced-by-count":61,"title":["Relationships Among Interleukin\u20106, Tumor Necrosis Factor\u2010\u03b1, Adipokines, Vitamin D, and Chronic Periodontitis"],"prefix":"10.1002","volume":"83","author":[{"given":"Flavia R.","family":"Teles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo P.","family":"Teles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigmund 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