{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:01:26Z","timestamp":1769637686616,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Trefoil factors (TFFs) are secreted molecules that are involved in cytoprotection against tissue damage and the immune response. TFFs have been detected in saliva and oral tissues, but their clinical significance has never been investigated in patients with chronic periodontitis. The objective of this study is to determine whether TFF expression in saliva and gingival tissues is associated with periodontal pathology.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Saliva and gingival tissue samples were collected from 25 non\u2010periodontitis individuals and 25 patients with chronic periodontitis (CP). Enzyme\u2010linked immunosorbent assay and immunohistochemical methods were used to evaluate the expression of TFFs (TFF1, TFF2, and TFF3) in saliva and gingival tissues, respectively. Periodontopathic bacteria were quantified by real\u2010time polymerase chain reaction.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Reduced salivary TFF1 and TFF3 concentrations were observed in patients with CP (<jats:italic>P<\/jats:italic> = 0.003 and <jats:italic>P<\/jats:italic> &lt;0.001, respectively). Decreased TFF3 expression in gingival tissues of patients with CP was demonstrated (<jats:italic>P<\/jats:italic> = 0.041). Levels of salivary TFF3 concentrations were negatively correlated with periodontal pathology and number of <jats:italic>Porphyromonas gingivalis<\/jats:italic> and <jats:italic>Tannerella forsythia<\/jats:italic> (formerly known as <jats:italic>Bacteroides forsythus<\/jats:italic>).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Altered expression of TFFs in saliva and gingival tissues was detected in patients with CP. The results suggest that TFF3 may be involved in the pathogenesis of periodontal disease.<\/jats:p>","DOI":"10.1902\/jop.2011.110431","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T13:18:19Z","timestamp":1324300699000},"page":"1129-1138","source":"Crossref","is-referenced-by-count":17,"title":["Trefoil Factors in Saliva and Gingival Tissues of Patients With Chronic Periodontitis"],"prefix":"10.1002","volume":"83","author":[{"given":"Ponlatham","family":"Chaiyarit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anek","family":"Chayasadom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nawarat","family":"Wara\u2010Aswapati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doodsadee","family":"Hormdee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sapatporn","family":"Sittisomwong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sirinun","family":"Nakaresisoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mie 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