{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:29:09Z","timestamp":1791217749602,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Interleukin\u201021 (IL\u201021) controls the differentiation of T\u2010helper Th17 cells and induces the production of IL\u201017 in this T\u2010cell subtype. The aim of this study is to determine the relative expression of IL\u201021 in gingival tissues of chronic periodontitis patients and correlate\/associate this expression with proinflammatory cytokines and clinical parameters of disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Samples of gingival biopsies were collected from chronic periodontitis patients (n = 10) and controls (n = 8). The mRNA expressions of IL\u201021, IL\u20101\u03b2, IL\u20106, IL\u201017, IL\u201023, IL\u201010, and transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21) were quantified using real\u2010time reverse transcription\u2010polymerase chain reaction. IL\u201021 levels were compared between chronic periodontitis and healthy gingival tissues and correlated with cytokine and clinical parameters of tissue destruction.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A significant overexpression of IL\u201021, IL\u20101\u03b2, IL\u20106, IL\u201017, and IL\u201023p19 was detected in periodontal disease\u2013affected tissues compared to healthy gingival tissues. IL\u201010 and TGF\u2010\u03b21 were, however, downregulated in periodontal lesions. IL\u201021 yielded significant positive correlations with probing depth, clinical attachment level, IL\u20101\u03b2, and IL\u20106. In addition, IL\u201021 was negatively correlated with IL\u201010 and TGF\u2010\u03b21.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> IL\u201021 was overexpressed in chronic periodontitis gingival tissues and correlated with clinical parameters of periodontal destruction and with proinflammatory cytokines. Therefore, IL\u201021 might play a role in the tissue destruction that characterizes chronic periodontal disease.<\/jats:p>","DOI":"10.1902\/jop.2011.110482","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T13:18:19Z","timestamp":1324300699000},"page":"948-954","source":"Crossref","is-referenced-by-count":57,"title":["Interleukin\u201021 Expression and Its Association With Proinflammatory Cytokines in Untreated Chronic Periodontitis Patients"],"prefix":"10.1002","volume":"83","author":[{"given":"Nicol\u00e1s","family":"Dutzan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Vernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose P.","family":"Vaque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Garc\u00eda\u2010Sesnich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loreto","family":"Abusleme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dezerega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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