{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:37:39Z","timestamp":1776872259270,"version":"3.51.2"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Bovine bone mineral (BBM) is extensively used as a filler material in periodontal reconstructive surgery of intrabony defects. Data are mostly available on the combined use of BBM with other biomaterials. The aim of this study is to evaluate healing after open\u2010flap debridement (OF) of intrabony periodontal defects alone or with adjunct treatment with BBM.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> After initial treatment, 32 patients with 32 intrabony periodontal defects participated in the study. Full\u2010thickness flaps were raised and root surfaces and defects were debrided. Patients were then randomly assigned to treatment groups, either OF alone or combined with defect fill with BBM, and followed in a strict postoperative maintenance care program for 12 months.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At 12 months, a mean \u00b1 SE gingival recession of 1.1 \u00b1 0.3 mm in OF and 0.9 \u00b1 0.4 mm in BBM occurred. Probing depth reduction was 4.0 \u00b1 0.5 mm in OF and 3.2 \u00b1 0.7 mm in BBM. Gain in clinical attachment level was 2.8 \u00b1 0.6 mm in OF and 2.3 \u00b1 0.8 mm in BBM. Probing bone level was reduced by 2.7 \u00b1 0.7 mm in OF and 1.8 \u00b1 1.1 mm in BBM. None of the above parameters showed significant intergroup differences. In contrast, radiographic defect depth change was significantly greater in BBM (3.4 \u00b1 2.3 mm) than in OF (1.9 \u00b1 1.7 mm).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Both treatments resulted in improved periodontal conditions. The adjunctive use of BBM in this study did not enhance the clinical result compared to OF alone.<\/jats:p>","DOI":"10.1902\/jop.2011.110490","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T18:02:32Z","timestamp":1323799352000},"page":"999-1007","source":"Crossref","is-referenced-by-count":12,"title":["A Randomized Study of Open\u2010Flap Surgery of 32 Intrabony Defects With and Without Adjunct Bovine Bone Mineral 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