{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:48:02Z","timestamp":1777369682831,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of the meta\u2010analysis is to explore the association between vitamin D receptor polymorphisms (including four gene loci: Taq\u2010I, Bsm\u2010I, Apa\u2010I, and Fok\u2010I) for susceptibility to periodontitis (either chronic [CP] or aggressive [AP]). Up to now, there has been only one systematic review focusing on this topic. We obtained some different findings compared with the previously published literature.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Nineteen case\u2010control studies were identified through a search of multiple electronic databases (from January 1, 1999 to June 30, 2011). The pooled odds ratios (ORs) and 95% confidence intervals (CIs) using codominant, dominant, and recessive genetic models from meta\u2010analysis were the main outcome measure. The Harbord test was used to detect the publication bias for each group.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Eighteen identified articles met the eligibility criteria. Through overall analyses, no statistical association was found between polymorphisms of the four gene loci and periodontitis. However, based on subgroup analyses, a significant association between the Taq\u2010I variants and CP rather than AP was shown in Asians (OR = 0.590; 95% CI = 0.425, 0.818) but not in whites (OR = 0.823; 95% CI = 0.637, 1.063). No statistically significant association was found between polymorphisms of Bsm\u2010I and Apa\u2010I with either AP or CP. The Fok\u2010I polymorphism showed a statistical association with AP (OR = 1.583; 95% CI = 1.157, 2.166) instead of CP (OR = 1.081; 95% CI = 0.638, 1.830) in Asians.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The results of the present meta\u2010analysis indicate the following: 1) the mutant allele t of the Taq\u2010I locus may be a protective factor for CP but not for AP in Asians, although this was not true in whites; 2) the mutant allele F of the Fok\u2010I locus appeared to be a risk factor for AP rather than CP in Asians; and 3) Bsm\u2010I and Apa\u2010I polymorphisms were found to have no significant associations with susceptibility to periodontitis (CP\/AP).<\/jats:p>","DOI":"10.1902\/jop.2011.110518","type":"journal-article","created":{"date-parts":[[2011,12,19]],"date-time":"2011-12-19T13:18:19Z","timestamp":1324300699000},"page":"1095-1103","source":"Crossref","is-referenced-by-count":36,"title":["Association Between Vitamin D Receptor Polymorphisms and Periodontitis: A Meta\u2010Analysis"],"prefix":"10.1002","volume":"83","author":[{"given":"Li\u2010li","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng\u2010peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010mei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_3_1","unstructured":"MillerAJ BrunelleJA CarlosJP BrownLJ L\u00f6eH. 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