{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:56:51Z","timestamp":1778810211595,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30872878"],"award-info":[{"award-number":["30872878"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> A relationship between periodontitis and chronic respiratory disease has been suggested by recent studies. The aim of this study is to explore the association between periodontitis and chronic obstructive pulmonary disease (COPD) in a Chinese population.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We conducted a case\u2010control study of 581 COPD cases and 438 non\u2010COPD controls. Lung function examination, a 6\u2010minute walk test, and the British Medical Research Council questionnaire were performed. Periodontal clinical examination index included probing depth (PD), attachment loss (AL), bleeding index (BI), plaque index (PI), and alveolar bone loss. A validated index for predicting COPD prognosis, the body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index, was also calculated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Participants with more severe COPD were more likely to have severe periodontal disease. PD, AL, PI, alveolar bone loss, and the number of teeth were significantly associated with all stages of COPD (all <jats:italic>P<\/jats:italic> &lt;0.001). When compared to controls (BODE = 0), participants with higher BODE scores had significantly higher AL (<jats:italic>P<\/jats:italic> &lt;0.001), BI (<jats:italic>P<\/jats:italic> = 0.027), PI (<jats:italic>P<\/jats:italic> &lt;0.001), alveolar bone loss (<jats:italic>P<\/jats:italic> &lt;0.001), and the number of teeth (<jats:italic>P<\/jats:italic> &lt;0.001). PI appeared to be the main periodontal health\u2010related factor for COPD, with an odds ratio (OR) = 9.01 (95% CI = 3.98 to 20.4) in the entire study population OR = 8.28 (95% CI = 2.36 to 29.0), OR = 5.89 (95% CI = 2.64 to 13.1), and OR = 2.46 (95% CI = 1.47 to 4.10) for current, smokers, and non\u2010smokers, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our study found a strong association between periodontitis and COPD, and PI seemed to be a major periodontal factor for predicting COPD among Chinese adults.<\/jats:p>","DOI":"10.1902\/jop.2012.110472","type":"journal-article","created":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T12:59:35Z","timestamp":1326718775000},"page":"1288-1296","source":"Crossref","is-referenced-by-count":59,"title":["Association Between Periodontitis and Chronic Obstructive Pulmonary Disease in a Chinese Population"],"prefix":"10.1002","volume":"83","author":[{"given":"Yan","family":"Si","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqing","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuomin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14416-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.4.873"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2007.06.028"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.06.00025805"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2010.04.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200703-456SO"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00220.x"},{"key":"e_1_2_7_9_1","unstructured":"XQ Qi 2008 People's Medical Publishing House Beijing 69 111"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.10.1172"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.72.9.1221"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2007.07.004"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.1.50"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2075"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1999.tb02263.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.251"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.78"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.59456"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.71"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5213.1665"},{"key":"e_1_2_7_21_1","first-page":"107","article-title":"Gingival sulcus bleeding. 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