{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:15:37Z","timestamp":1770696937139,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of the present study is to assess clinical, microbiologic, and immunologic benefits of amoxicillin\/metronidazole (AM) when performing full\u2010mouth ultrasonic debridement (FMUD) in generalized aggressive periodontitis (GAgP) treatment.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010four GAgP patients were divided into two groups: the FMUD group (n = 12), which received FMUD plus placebo, and the FMUD+AM group (n = 12), which received FMUD and 375 mg amoxicillin plus 250 mg metronidazole for 7 days. The following clinical outcomes were tested: plaque and bleeding on probing indices, pocket probing depth (PD), relative gingival margin position (GMP), and relative clinical attachment level (CAL). Total amount of <jats:italic>Porphyromonas gingivalis<\/jats:italic> (<jats:italic>Pg<\/jats:italic>), <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> (<jats:italic>Aa<\/jats:italic>), <jats:italic>Tannerella forsythia<\/jats:italic> (<jats:italic>Tf<\/jats:italic>), and gingival crevicular fluid (GCF) concentration of interleukin (IL)\u201010 and IL\u20101\u03b2 were also determined. All clinical, microbiologic, and immunologic parameters were assessed at baseline and at 3 and 6 months post\u2010therapy. The ANOVA\/Tukey test was used for statistical analysis (\u03b1 = 5%).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Amoxicillin\/metronidazole used as an adjunct to the FMUD protocol added clinical and microbiologic benefits to GAgP treatment (<jats:italic>P<\/jats:italic> &lt;0.05). FMUD+AM groups presented an additional PD reduction in initially deep PDs at the 3\u2010month follow\u2010up (3.99 \u00b1 1.16 mm and 3.09 \u00b1 0.78 mm for FMUD+AM and FMUD, respectively; <jats:italic>P<\/jats:italic> &lt;0.05), a lower number of residual pockets at the 3\u2010 and 6\u2010month follow\u2010ups, and a statistical reduction in amounts of <jats:italic>Aa<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt;0.05). Analysis of <jats:italic>Tf<\/jats:italic> and <jats:italic>Pg<\/jats:italic> amounts, as well as IL\u201010 and IL\u20101\u03b2 GCF concentrations failed to demonstrate a difference between the groups (<jats:italic>P<\/jats:italic> &gt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> It may be concluded that amoxicillin\/metronidazole improves clinical and microbiologic results of FMUD in GAgP treatment.<\/jats:p>","DOI":"10.1902\/jop.2012.110513","type":"journal-article","created":{"date-parts":[[2012,1,30]],"date-time":"2012-01-30T09:51:06Z","timestamp":1327917066000},"page":"988-998","source":"Crossref","is-referenced-by-count":59,"title":["The Combination of Amoxicillin and Metronidazole Improves Clinical and Microbiologic Results of One\u2010Stage, Full\u2010Mouth, Ultrasonic Debridement in Aggressive Periodontitis Treatment"],"prefix":"10.1002","volume":"83","author":[{"given":"Renato 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