{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:37:04Z","timestamp":1788871024407,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["1130408"],"award-info":[{"award-number":["1130408"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    This study examines the efficacy of azithromycin in combination with non\u2010surgical periodontal therapy on clinical and microbiologic parameters and gingival crevicular fluid (GCF) matrix metalloproteinases\u20108 (MMP\u20108) levels over 6 months in patients with severe generalized chronic periodontitis (CP).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Twenty\u2010eight of 36 patients with severe generalized CP were included in this randomized, double\u2010masked, placebo\u2010controlled, parallel\u2010arm study. They were randomly assigned to azithromycin or placebo groups (500 mg, once daily for 3 days). Probing depth (PD), clinical attachment level, dichotomous presence or absence of supragingival plaque accumulation, and bleeding on probing were recorded. GCF samples were obtained from one single\u2010rooted tooth with PD \u2265 6 mm, whereas microbiologic samples were collected from two single\u2010rooted teeth with PD \u2265 6 mm. Microbiologic parameters were analyzed by quantitative real\u2010time polymerase chain reaction for\n                    <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>\n                    ,\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    ,\n                    <jats:italic>Tannerella forsythia<\/jats:italic>\n                    ,\n                    <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    ,\n                    <jats:italic>Prevotella intermedia<\/jats:italic>\n                    , and total bacteria. GCF MMP\u20108 levels were determined by immunofluorescence assay.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Azithromycin and placebo groups demonstrated similar but significant improvements in all clinical parameters (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05).\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    ,\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    ,\n                    <jats:italic>T. forsythia<\/jats:italic>\n                    ,\n                    <jats:italic>P. intermedia<\/jats:italic>\n                    , and total bacteria significantly decreased over the 6\u2010month period in both groups, whereas\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    was significantly reduced in all visits in the azithromycin group, with the levels also being lower compared with those of the placebo group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). The azithromycin and placebo groups exhibited significant reduction in GCF MMP\u20108 levels at the post\u2010treatment visit and at 2 weeks (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    On the basis of the present findings, it can be concluded that adjunctive azithromycin provides no additional benefit over non\u2010surgical periodontal treatment on parameters investigated in patients with severe generalized CP.\n                  <\/jats:p>","DOI":"10.1902\/jop.2012.110519","type":"journal-article","created":{"date-parts":[[2012,2,11]],"date-time":"2012-02-11T03:03:59Z","timestamp":1328929439000},"page":"1480-1491","source":"Crossref","is-referenced-by-count":43,"title":["Azithromycin as an Adjunctive Treatment of Generalized Severe Chronic Periodontitis: Clinical, Microbiologic, and Biochemical Parameters"],"prefix":"10.1002","volume":"83","author":[{"given":"Buket","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclnur","family":"Emingil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcven","family":"\u00d6zdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taina","family":"Tervahartiala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caner","family":"Vural","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl","family":"Atilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haluk","family":"Baylas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080213"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00191.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00199.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600800103"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027005366.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100196"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.8s.744"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411990100030101"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.115"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01260.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/25.suppl_A.73"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01321-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.12.1206"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.9.960"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060246"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290109.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.3.426"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01040.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060247"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090067"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070072"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01607.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01254.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01766.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.32"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.11s.13"},{"key":"e_1_2_7_29_1","unstructured":"CimasoniG. 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