{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:27:45Z","timestamp":1791311265115,"version":"4.3.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The great variability of periodontal and systemic responses to experimental periodontitis reflects the inherent pathogenic complexity of mice models and could limit the resulting interpretations and their extension to human diseases. This study compared the effect of <jats:italic>Porphyromonas gingivalis<\/jats:italic> (<jats:italic>Pg<\/jats:italic>) infection and experimental periodontitis duration at local and systemic levels in various models.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Periodontitis was induced in C57BL\/6J mice by ligatures previously incubated with <jats:italic>Pg<\/jats:italic> (LIGPG group) or not (LIG group) or by oral gavage (GAV) with <jats:italic>Pg<\/jats:italic> ATCC 33277. Blood samples were taken, and mice were euthanized at different times. Periodontal tissue destruction, osteoclast number, and inflammation were assessed by histomorphometry, tartrate\u2010resistant acid phosphatase histoenzymology, and cathepsin B (CATB) and matrix metalloproteinase 9 (MMP9) immunochemistry. Serum levels of interleukin\u20106 (IL\u20106) and IL\u20101\u03b2 were measured using enzyme\u2010linked immunosorbent assay bioplex methods.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Periodontal tissue destruction and osteoclast numbers were significantly elevated in LIGPG models compared to LIG and GAV models. They increased with time with the exception of osteoclast numbers in the LIG model. CATB and MMP9 expression was related to bone destruction processes and <jats:italic>Pg<\/jats:italic> infection. The highest serum levels of IL\u20106 and IL\u20101\u03b2 were observed in the LIGPG group. A decrease of IL\u20106 and an increase of IL\u20101\u03b2 serum level were observed with time in LIGPG group contrary to LIG group.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> These data indicate that <jats:italic>Pg<\/jats:italic> infection worsened periodontal tissue destruction through specific pathogenic pathways and modified systemic response to periodontal inflammation. Furthermore, the blood cytokine response to ligature models showed their relevance for evaluating the systemic impact of periodontal disease.<\/jats:p>","DOI":"10.1902\/jop.2012.110540","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T11:50:41Z","timestamp":1338551441000},"page":"396-406","source":"Crossref","is-referenced-by-count":63,"title":["Periodontal and Systemic Responses in Various Mice Models of Experimental Periodontitis: Respective Roles of Inflammation Duration and <i>Porphyromonas gingivalis<\/i> 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