{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:41:24Z","timestamp":1760870484529,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The objective of this study is to compare cyclooxygenase\u20102 (COX\u20102) protein expression in gingival biopsies from patients with chronic periodontitis (CP), patients with gingivitis (GV), and individuals with no periodontal disease (control group) and to establish its relationship with clinical variables and connective tissue loss in the lamina propria.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A cross\u2010sectional and analytic study was conducted in 108 gingival biopsies from 52 patients with CP, 39 with GV, and 17 controls. All biopsies were processed for conventional histopathologic study, immunohistochemical determination of COX\u20102 protein expression, and automatic quantification of connective tissue by image analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The protein expression of COX\u20102, mainly produced by plasma cells and monocytes, was significantly related to the presence of periodontal disease, bleeding index, intensity of inflammatory infiltrate, and loss of connective tissue in the lamina propria of gingival biopsies (<jats:italic>P<\/jats:italic> &lt;0.01, Spearman test). COX\u20102 expression was also directly correlated with attachment loss (<jats:italic>P<\/jats:italic> &lt;0.05, Spearman test).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> COX\u20102 protein expression is higher in patients with GV and CP than in individuals without periodontal disease and is inversely correlated with the amount of connective tissue in the lamina propria as determined by image analysis. This finding suggests that COX\u20102 participates in mechanisms and pathway signaling related to the destruction of fibrillar support structures of the periodontium.<\/jats:p>","DOI":"10.1902\/jop.2012.110561","type":"journal-article","created":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T17:18:18Z","timestamp":1328894298000},"page":"1538-1545","source":"Crossref","is-referenced-by-count":14,"title":["Cyclooxygenase\u20102 Expression in Gingival Biopsies From Periodontal Patients Is Correlated With Connective Tissue 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