{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:33:11Z","timestamp":1773369191247,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The balance (ratio) of anti\u2010inflammatory and proinflammatory cytokines is thought to play an important role in the pathogenesis of chronic periodontitis. Moreover, the imbalance of anti\u2010inflammatory\/proinflammatory cytokines may modulate disease progression in aggressive periodontitis (AgP). This study aims to investigate the levels of interleukin (IL)\u201011 and IL\u201017 and their ratio in gingival crevicular fluid (GCF) in patients with AgP.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This study included 20 patients with generalized AgP (GAgP) and 18 healthy controls (HC). For each patient, the values of clinical parameters, such as gingival index, plaque index, probing depth, and clinical attachment level, were recorded. Levels of IL\u201011 and IL\u201017 in GCF samples were evaluated using enzyme\u2010linked immunosorbent assay. The values of clinical parameters, cytokine levels, and the ratios of cytokines were evaluated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The values of all the clinical parameters were significantly higher in the GAgP group than in the HC group (<jats:italic>P<\/jats:italic> &lt;0.001). The total amount and concentration of IL\u201011 and the concentration of the IL\u201017 and IL\u201011\/IL\u201017 ratio were significantly lower in the GAgP group than in the HC group (<jats:italic>P<\/jats:italic> &lt;0.001). The total amount of IL\u201017 was not significantly different between the groups (<jats:italic>P<\/jats:italic> = 0.317)<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The IL\u201011\/IL\u201017 ratio was decreased in the GAgP group because of the decreased IL\u201011 levels. The IL\u201011\/IL\u201017 axis and the link between IL\u201017 and neutrophil function disorders in AgP should be investigated to clarify the role of the IL\u201011\/IL\u201017 axis and its balance and imbalance in the pathogenesis of AgP.<\/jats:p>","DOI":"10.1902\/jop.2012.110585","type":"journal-article","created":{"date-parts":[[2012,1,16]],"date-time":"2012-01-16T12:59:35Z","timestamp":1326718775000},"page":"1425-1431","source":"Crossref","is-referenced-by-count":32,"title":["The Gingival Crevicular Fluid Levels of Interleukin\u201011 and Interleukin\u201017 in Patients With Aggressive Periodontitis"],"prefix":"10.1002","volume":"83","author":[{"given":"Zuhal Yetkin","family":"Ay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclin","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhsin","family":"\u00d6zdem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Havva","family":"Ko\u00e7ak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Recep","family":"S\u00fct\u00e7\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersin","family":"Uskun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine \u00d6zt\u00fcrk","family":"Tongu\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma 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