{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T04:04:58Z","timestamp":1778299498771,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Serum leptin concentrations are reported to be elevated in patients with periodontal diseases and may have a modulating role in cardiovascular diseases. Serum leptin concentrations have not been assessed in periodontitis associated with acute myocardial infarction (AMI) to date. The purpose of this study was to assess the concentration of serum leptin in periodontitis associated with AMI.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A cross\u2010sectional clinical study was conducted comprising a sample size of 120 participants divided into four groups (n = 30 each) based on their clinical signs: 1) control; 2) AMI; 3) generalized chronic periodontitis (GCP); and 4) GCP + AMI. Body mass index (BMI) was calculated and recorded for all the subjects based on BMI chart of the World Health Organization. After thorough clinical and oral examination, plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment loss (AL) were recorded. In addition, 2 mL venous blood was collected by venipuncture from all participants to determine serum leptin concentration using the enzyme\u2010linked immunosorbent assay method.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A strong correlation of serum leptin concentration to BMI was observed in AMI, GCP, and GCP + AMI groups. Serum leptin levels were significantly elevated in AMI, GCP, and GCP + AMI groups compared to the control group. Significant associations between serum leptin concentration and PI, GI, PD, and AL were also seen in the GCP group. PI, GI, PD, and AL were statistically significantly elevated in GCP + AMI and AMI groups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Elevated serum leptin concentration was associated with increased BMI, GCP, and AMI and may serve as a risk marker for these conditions.<\/jats:p>","DOI":"10.1902\/jop.2012.110620","type":"journal-article","created":{"date-parts":[[2012,5,25]],"date-time":"2012-05-25T18:31:51Z","timestamp":1337970711000},"page":"917-924","source":"Crossref","is-referenced-by-count":19,"title":["Association of Leptin in Periodontitis and Acute Myocardial Infarction"],"prefix":"10.1002","volume":"85","author":[{"given":"Rupasree","family":"Gundala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay K.","family":"Chava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ramalingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00196.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/314963"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02190.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01078.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.2.426"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2000.41.1.68"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh0901.090975"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.1.583"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_7_13_1","first-page":"27","article-title":"Ultra\u2010sensitive C\u2010reactive protein (US\u2010CRP) in patients with periodontal disease and risk of acute myocardial infarction","volume":"2","author":"Lattore CU","year":"2011","journal-title":"Cardiol Rev"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.06.037"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.127"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.2.293"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.6.783"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-978967"},{"key":"e_1_2_7_19_1","first-page":"R204","article-title":"IL\u20101 \u03b2 mediates leptin induction during inflammation","volume":"274","author":"Faggioni R","year":"1998","journal-title":"Am J Physiol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.1.171"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.276.4.E658"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/515349"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1998.tb00829.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00571.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.72.9.1254"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050277"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc5001.101061"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007383200"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10s.1123"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2075"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2012.110620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:19:21Z","timestamp":1760876361000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2012.110620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1902\/jop.2012.110620"],"URL":"https:\/\/doi.org\/10.1902\/jop.2012.110620","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}