{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:20:42Z","timestamp":1782166842785,"version":"3.54.5"},"reference-count":93,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study is to perform an updated systematic review and meta\u2010analysis of randomized controlled trials (RCTs) evaluating the efficacy of scaling and root planing (SRP) in reducing the preterm\u2010birth and low\u2010birth\u2010weight risks to analyze important subgroups and to further explore heterogeneity and bias risks in the pooled studies.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The entire Cochrane Library was searched (from 1990 to September 2011), MEDLINE (from 1950 to September 2011), CINAHL (from 1980 to September 2011), University of Michigan School of Dentistry \u201cDentistry and Oral Sciences\u201d database (from 1990 to September 2011), conference proceedings, and the <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> database. Authors were contacted when clarification was needed. Selection criteria included the following: 1) RCTs that reported preterm\u2010birth risk (&lt;37 weeks) outcomes, 2) compared SRP treatment to either placebo or no treatment in pregnant patients with periodontitis, and 3) had a probing depth &gt;4 mm or clinical attachment loss &gt;2 mm for \u22651 site. Reviewers independently extracted data from each included study using a standardized, piloted form and assessed quality using a risk\u2010of\u2010bias tool modeled after Cochrane, and discrepancies were resolved. A random\u2010effects model was used to calculate relative risks and 95% confidence intervals (CIs) for pooled data. For subgroup analysis with heterogeneity &lt;50%, a fixed\u2010effects model was used.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> After abstract review, 12 studies were identified by the search, and 11 were included in the main meta\u2010analysis (preterm birth &lt;37 weeks). Overall quality and design of included studies was fair or good. For the main meta\u2010analysis, results ranged from risk ratio with periodontal treatment 0.14 (95% CI = 0.01, 2.55) to 1.24 (95% CI = 0.93, 1.67) for an overall risk ratio of 0.81 (95% CI = 0.64, 1.02). When analyzed separately by subgroup for excess prematurity risk, the high\u2010risk group (overall prematurity of 22.2% to 62.8%) showed combined risk ratios of 0.66 (95% CI = 0.54, 0.80). Remaining studies (overall prematurity of 4.0% to 10.4%) showed combined risk ratio of 0.97 (95% CI = 0.75, 1.24).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> This systematic review and meta\u2010analysis indicates statistically significant effect in reducing risk of preterm birth for SRP in pregnant women with periodontitis for groups with high risks of preterm birth only. Future research should attempt to confirm these findings and further define groups in which risk reduction may be effective.<\/jats:p>","DOI":"10.1902\/jop.2012.110636","type":"journal-article","created":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T08:24:17Z","timestamp":1330590257000},"page":"1508-1519","source":"Crossref","is-referenced-by-count":63,"title":["Scaling and Root Planing Treatment for Periodontitis to Reduce Preterm Birth and Low Birth Weight: A Systematic Review and Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"83","author":[{"given":"Arthur J.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Pullin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darneesh S.","family":"Thornton\u2010Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem Y.","family":"Karimbux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.8.1406"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2004.31.10.570"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb02076.x"},{"key":"e_1_2_7_5_1","first-page":"E175","article-title":"Type 1 diabetes mellitus and periodontal disease: relationship to different clinical variables","volume":"14","author":"Silvestre FJ","year":"2009","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.6.779"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780401221"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.12.1764"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10s.1103"},{"key":"e_1_2_7_10_1","first-page":"233","article-title":"Periodontal disease and preterm birth relationship","volume":"57","author":"Sacco G","year":"2008","journal-title":"Minerva Stomatol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070554"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2001.0306"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(03)00617-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.10.892"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090236"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.09.020"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181c15b40"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02713.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b1341f"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01761.x"},{"key":"e_1_2_7_21_1","unstructured":"HigginsJPT GreenS.Cochrane Handbook for Systematic Reviews of Interventions v.5.0.2(updated September 2009). 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