{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:36:13Z","timestamp":1790789773753,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005634","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riseura Apollonia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007650","name":"Suomen Hammasl\u00e4\u00e4k\u00e4riliitto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007650","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold><jats:bold>:<\/jats:bold> The aim of this study is to examine the relationship of selected systemic and oral health parameters and the salivary presence of six periodontal pathogens to age\u2010related macular degeneration (AMD).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The present cross\u2010sectional study includes data on 1,751 individuals (\u226530 years old). General health information was obtained by questionnaires and interviews, including self\u2010reported diagnosis of AMD, as well as by the general and oral health examination, including panoramic radiography and laboratory analyses. Fifty\u2010four individuals with degenerative fundus changes formed the AMD group, and the other 1,697 formed the non\u2010AMD group. Pearson \u03c7<jats:sup>2<\/jats:sup> and analysis of variance tests were used for comparisons of categorical parameters and continuous parameters between the participant groups, respectively. A logistic regression analysis was performed to study the association of AMD with alveolar bone loss and the number of teeth by controlling for age, diabetic status, systolic blood pressure, education, and smoking, and also for the carriage of salivary bacteria.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Advanced age, systolic blood pressure, and diabetes were associated with AMD (<jats:italic>P<\/jats:italic> &lt;0.001), whereas the carriage rates of the examined periodontal pathogens were not. In the whole study population, the participants with AMD had fewer teeth (<jats:italic>P<\/jats:italic> &lt;0.001) and more alveolar bone loss (<jats:italic>P<\/jats:italic> = 0.004) compared with non\u2010AMD participants. In a logistic regression model adjusted for age, smoking, and diabetes, alveolar bone loss was associated with AMD in males with an odds ratio of 4.3 (95% confidence interval = 1.3 to 14.6, <jats:italic>P<\/jats:italic> = 0.013).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In this population\u2010based health survey, alveolar bone loss is independently associated with AMD in males.<\/jats:p>","DOI":"10.1902\/jop.2012.110643","type":"journal-article","created":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T11:59:53Z","timestamp":1331639993000},"page":"58-67","source":"Crossref","is-referenced-by-count":36,"title":["Alveolar Bone Loss Associated With Age\u2010Related Macular Degeneration in Males"],"prefix":"10.1002","volume":"84","author":[{"given":"Petteri","family":"Karesvuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulvi K.","family":"Gursoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirkko J.","family":"Pussinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Suominen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisko","family":"Huumonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"Vesti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"K\u00f6n\u00f6nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"844","article-title":"Global data on visual impairment in the year 2002","volume":"82","author":"Resnikoff S","year":"2004","journal-title":"Bull World Health Organ"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.4.529"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01566.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.14.7.835"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0b013e3180377936"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.87.5.523"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-1434"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.03.018"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00448-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31802e3e9b"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0223"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.6.704"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.11.020"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.10.1396"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2009.11.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2010.18"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.12.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_7_20_1","unstructured":"Suominen\u2010TaipaleL NordbladA VehkalahtiM AromaaA eds.Oral Health in Finnish Adult Population. Health 2000 Survey. 2008. Publications of the National Public Health Institute Helsinki Finland B25\/2008. Helsinki Finland: National Public Health Institute; 2008."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01173.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.106.138743"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.711507"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6676.779"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.38"},{"key":"e_1_2_7_26_1","first-page":"221","article-title":"Ocular inflammation of dental origin (in French)","volume":"65","author":"Cordier J","year":"1965","journal-title":"Bull Soc Ophtalmol Fr"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-2-47"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.03.021"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1698901"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728220902942322"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01703.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02560-06"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-08-0571"},{"key":"e_1_2_7_34_1","unstructured":"ReunanenA KattainenA KnektP MarniemiJ SundvallS. Working group for cardiovascular diseases. Risk factors. In: Aromaa A Koskinen S eds.Health and Functional Capacity in Finland. Baseline Results of the Health 2000 Health Examination Survey 2004. Publications of the National Public Health Institute Helsinki Finland B12\/2004. Helsinki Finland: National Public Health Institute; 2004."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.1.157-160.1998"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.11.3504-3508.1999"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1996.tb00180.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.4.1057-1061.1999"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2415-10-31"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510381902"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01699.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080233"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2008.01038.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/621484"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01480.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.7.828"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500703"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2125"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2009.09.001"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2012.110643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:48:34Z","timestamp":1760870914000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2012.110643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1902\/jop.2012.110643"],"URL":"https:\/\/doi.org\/10.1902\/jop.2012.110643","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}