{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:09:39Z","timestamp":1792447779352,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Non\u2010surgical periodontal treatment decreases serum levels of inflammatory cytokines in patients with and without obesity. However, the changes in metabolic parameters in association with these decreases in levels of inflammatory markers by periodontal treatment have not been evaluated in patients with obesity. The aim of this study is to evaluate the short\u2010term changes in systemic inflammatory, lipid, and glucose parameters in the presence of obesity after periodontal treatment.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study included 22 dyslipemic patients with obesity and 24 healthy individuals without obesity with generalized chronic periodontitis. The periodontal parameters, anthropometric measurements, and serum levels of triglyceride, total cholesterol, high\u2010density lipoprotein cholesterol, low\u2010density lipoprotein cholesterol, and lipoprotein\u2010a, high\u2010sensitive C\u2010reactive protein, fasting blood glucose, insulin, interleukin\u20106 (IL\u20106), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and leptin were measured. A homeostasis model assessment of the insulin resistance (HOMA\u2010IR) score was calculated before and 3 months after non\u2010surgical periodontal treatment.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Both groups responded well to the periodontal treatment in terms of periodontal parameters. The treatment was also associated with a decrease in serum TNF\u2010\u03b1 and IL\u20106 levels and HOMA\u2010IR scores in individuals with obesity and with a decrease in IL\u20106 levels in patients without obesity. Conversely, there were insignificant decreases in lipid profiles and serum fasting glucose of patients with obesity.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The non\u2010surgical periodontal treatment causes a decrease in the levels of some circulating proinflammatory cytokines and may be associated with a decrease in insulin resistance in the obese population.<\/jats:p>","DOI":"10.1902\/jop.2012.110646","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T08:40:41Z","timestamp":1329813641000},"page":"13-23","source":"Crossref","is-referenced-by-count":70,"title":["Changes in Inflammatory and Metabolic Parameters After Periodontal Treatment in Patients With and Without Obesity"],"prefix":"10.1002","volume":"84","author":[{"given":"Umut","family":"Altay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem 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