{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:12:14Z","timestamp":1789711934187,"version":"4.0.1"},"reference-count":77,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Interleukin\u20101 (IL\u20101) gene polymorphisms have been associated with increased levels of inflammatory mediators and several inflammatory diseases. Periodontitis is a bacterially induced chronic inflammatory disease that destroys the connective tissues and bone that support the teeth, affects substantial numbers of adults, and has been implicated as a contributing factor in systemic diseases. IL\u20101 gene polymorphisms, most prominently <jats:italic>IL1A<\/jats:italic> (\u2212889), <jats:italic>IL1A<\/jats:italic> (+4845), and <jats:italic>IL1B<\/jats:italic> (+3954), have been associated with chronic periodontitis (CP) in whites. Since the first report, \u2265125 studies have examined IL\u20101 gene variation in relation to periodontal disease. These studies have produced mixed findings in diverse periodontal phenotypes and in different ethnic groups. One previous meta\u2010analysis has been published on this topic and supported an association between IL\u20101 genes and periodontitis, but considerable doubt remains about the patient populations in which the association may be of clinical relevance.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A systematic review and meta\u2010analysis was conducted in an attempt to clarify whether IL\u20101 gene variants were associated with well\u2010defined clinical phenotypes of CP in white patients. Study inclusion criteria focused on the analytic framework originally proposed for the IL\u20101 genetic effect in which overexpression of inflammatory mediators is hypothesized to result in more severe periodontitis in response to a bacterial challenge.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Twenty\u2010seven studies were included in the qualitative analysis. Nineteen studies yielded significant associations between carriage of the minor IL\u20101 alleles and periodontitis. The meta\u2010analysis, based on 13 qualifying studies, found significant effects for the two individual gene variations (<jats:italic>IL1A<\/jats:italic> odds ratio [OR] = 1.48; <jats:italic>IL1B<\/jats:italic> OR = 1.54) and for a composite genotype that combines minor alleles at each locus (OR = 1.51). Statistically significant heterogeneity was found that could not be explained, but there was no indication of publication bias.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This review and meta\u2010analysis show that <jats:italic>IL1A<\/jats:italic> and <jats:italic>IL1B<\/jats:italic> genetic variations are significant contributors to CP in whites.<\/jats:p>","DOI":"10.1902\/jop.2012.110655","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T08:40:41Z","timestamp":1329813641000},"page":"1407-1419","source":"Crossref","is-referenced-by-count":112,"title":["Interleukin\u20101 Gene Polymorphisms and Chronic Periodontitis in Adult Whites: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"83","author":[{"given":"Nadeem Y.","family":"Karimbux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veeral 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