{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T21:27:41Z","timestamp":1771536461324,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> In this study, we compare the effects of enamel matrix derivative (EMD) associated with a hydroxyapatite and \u03b2\u2010tricalcium phosphate (HA\/\u03b2\u2010TCP) implant to EMD alone and to open\u2010flap debridement (OFD) when surgically treating 1\u2010 to 2\u2010wall intrabony defects.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010four patients, exhibiting \u22653 intraosseous defects in different quadrants, were each treated by OFD, EMD, or EMD + HA\/\u03b2\u2010TCP in each defect. At baseline and 12 and 24 months, a complete clinical and radiographic examination was done. Pre\u2010therapy and post\u2010therapy clinical (probing depth [PD], clinical attachment level [CAL], and gingival recession [GR]) and radiographic (defect bone level [DBL] and radiographic bone gain [RBG]) parameters for the different treatments were compared.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> After 12 and 24 months, almost all the clinical and radiographic parameters showed significant changes from baseline within each group (<jats:italic>P<\/jats:italic> &lt;0.001). Differences in PD, CAL, and DBL scores were also seen among the three groups at the 12\u2010 and 24\u2010month visits (<jats:italic>P<\/jats:italic> &lt;0.001). At 12 and 24 months after treatment, the EMD + HA\/\u03b2\u2010TCP group showed significantly greater PD reduction (4.00 \u00b1 0.42 mm; 4.25 \u00b1 0.63 mm), CAL gain (3.47 \u00b1 0.65 mm; 3.63 \u00b1 0.91 mm), and RBG (3.17 \u00b1 0.69 mm; 3.35 \u00b1 0.80 mm) and less GR increase (0.56 \u00b1 0.37 mm; 0.63 \u00b1 0.42 mm) compared with the OFD and EMD groups (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our data support the hypothesis that the adjunct of an HA\/\u03b2\u2010TCP composite implant with EMD may improve the clinical and radiographic outcomes of the surgical treatment of unfavorable intrabony defects.<\/jats:p>","DOI":"10.1902\/jop.2012.110656","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T16:10:03Z","timestamp":1337616603000},"page":"444-455","source":"Crossref","is-referenced-by-count":43,"title":["Enamel Matrix Derivative, Alone or Associated With a Synthetic Bone Substitute, in the Treatment of 1\u2010 to 2\u2010Wall Periodontal Defects"],"prefix":"10.1002","volume":"84","author":[{"given":"Dario","family":"De Leonardis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Paolantonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00247.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00249.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.1.31"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.8.1287"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.01607.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028002181.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00250.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00248.x"},{"key":"e_1_2_7_10_1","first-page":"374","article-title":"Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative (Emdogain)","volume":"20","author":"Sculean A","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00253.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290407.x"},{"key":"e_1_2_7_13_1","first-page":"8","article-title":"Enamel matrix derivative for periodontal reconstructive surgery: Technique and clinical and histologic case report","volume":"19","author":"Mellonig JT","year":"1999","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.12.1725"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.7.1110"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060142"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.4.433"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2236"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.10.1309"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00635.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01217.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080009"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.9.729"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.12.1639"},{"key":"e_1_2_7_26_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J","year":"1975","journal-title":"Int Dent J"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.4.261"},{"key":"e_1_2_7_28_1","first-page":"589","article-title":"The simplified papilla preservation flap. A novel surgical approach for the management of soft tissues in regenerative procedures","volume":"19","author":"Cortellini P","year":"1999","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.12.1821"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.1.25"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1971.42.10.648"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027002104.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500605"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01265.x"},{"key":"e_1_2_7_35_1","first-page":"CD003875","article-title":"Enamel matrix derivative (Emdogain(R)) for periodontal tissue regeneration in intrabony defects","volume":"4","author":"Esposito M","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_36_1","first-page":"127","article-title":"A case report study of 72 consecutive Emdogain\u2010treated intrabony periodontal defects: Clinical and radiographic findings after 1 year","volume":"20","author":"Heden G","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.5.752"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.5.501"},{"key":"e_1_2_7_39_1","first-page":"157","article-title":"Treatment of intrabony periodontal defects with an enamel matrix protein derivative (Emdogain): A report of 32 cases","volume":"19","author":"Sculean A","year":"1999","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100144"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290508.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.10146.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2008.01565.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070146"},{"issue":"2","key":"e_1_2_7_45_1","first-page":"22","article-title":"The clinical significance of local chemotherapies","volume":"29","author":"Killoy WJ","year":"2002","journal-title":"J Clin Periodontol"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1986.tb01482.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb02249.x"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.4.559"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90034-6"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.11.1183"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2012.110656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:50:26Z","timestamp":1760867426000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2012.110656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1902\/jop.2012.110656"],"URL":"https:\/\/doi.org\/10.1902\/jop.2012.110656","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}