{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:29:09Z","timestamp":1787023749983,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Simvastatin has been shown to stimulate new bone growth on rat mandibles, but much of the bone is lost over time. The purpose of this study is to evaluate the impact of a locally or systemically applied antiresorptive agent (alendronate) on simvastatin\u2010induced bone formation in and adjacent to a rat periodontal defect.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Fenestration defects were created over mandibular molar roots in 65 mature female Sprague\u2010Dawley rats. Two weeks later, animals were divided into eight groups of eight to nine rats, and three weekly injections around the defect were applied: 1) 0.5 mg simvastatin in ethanol (SIM\u2010EtOH); 2) 0.5 mg simvastatin in alendronate\u2013cyclodextrin conjugate (SIM\u2010ALN\u2010CD); 3) EtOH alone; 4) ALN\u2010CD alone; or 5) no injections. Twenty\u2010four animals were evaluated for new bone width around the defect 21 days after the last injections (short\u2010term) and 41 rats were followed for 48 days (long\u2010term). Three SIM\u2010EtOH groups of long\u2010term rats also were subjected to 2 weeks of daily systemic ALN or saline either during or 3 to 4 weeks after SIM\u2010EtOH injections. Decalcified, hematoxylin\u2010and\u2010eosin\u2010stained cross\u2010sections of the defect area were analyzed for new bone width and groups were compared using mixed\u2010model analyses of variance.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    All groups showed nearly 100% bone fill, with no differences among the short\u2010term groups. However, in the long\u2010term animals, two\u2010fold to three\u2010fold more new bone width (\u22640.004) was seen around the periphery of the defect with the use of systemic ALN after SIM\u2010EtOH injections (0.93 \u00b1 0.12 and 0.78 \u00b1 0.11 mm with early and late systemic ALN, respectively) compared to local SIM\/ALN\u2010CD preparations (0.32 \u00b1 0.10 mm) or short\u2010term SIM\u2010EtOH injections (0.35 \u00b1 0.10 mm). No significant new cementum formation or ankylosis was noted.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The use of a short course of systemic ALN during the healing period after bone anabolic SIM injections has the potential to enhance local bone augmentation.\n                  <\/jats:p>","DOI":"10.1902\/jop.2012.110683","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T04:55:42Z","timestamp":1331873742000},"page":"1463-1471","source":"Crossref","is-referenced-by-count":29,"title":["Impact of Local and Systemic Alendronate on Simvastatin\u2010Induced New Bone Around Periodontal Defects"],"prefix":"10.1002","volume":"83","author":[{"given":"Amy C.","family":"Killeen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pota 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