{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:38:39Z","timestamp":1791171519080,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Simvastatin (SMV) assists in bone regeneration and has an anti\u2010inflammatory effect when delivered or applied locally. The present clinical trial is designed to investigate the effectiveness of 1.2\u2010mg SMV as a local drug delivery system as an adjunct to scaling and root planing (SRP) for the treatment of Class II furcation defects.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Seventy\u2010two patients with mandibular buccal Class II furcation defects were randomized and categorized into two treatment groups: SRP plus placebo (group 1) and SRP plus 1.2\u2010mg SMV (group 2). Clinical parameters were recorded at baseline before SRP and at 3 and 6 months; they included modified sulcus bleeding index (mSBI), probing depth (PD), and relative vertical (RVAL) and horizontal (RHAL) attachment levels. At baseline and after 6 months, radiologic assessment of bone defect fill was performed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Both therapies resulted in significant improvements. The decrease in mSBI score at 6 months was greater in group 2 (2.02 \u00b1 0.23) compared with group 1 (1.80 \u00b1 0.22). The mean decrease in PD at 6 months was 1.30 \u00b1 1.0 and 4.05 \u00b1 1.31 mm in groups 1 and 2, respectively. A significantly greater gain in mean RVAL and RHAL was found in group 2 than in group 1 (<jats:italic>P<\/jats:italic> &lt;0.05). Furthermore, significantly greater mean percentage of bone fill was found in group 2 (25.16%) compared with group 1 (1.54%).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Locally delivered SMV provides a comfortable and flexible method to improve clinical parameters and also to enhance bone formation.<\/jats:p>","DOI":"10.1902\/jop.2012.110716","type":"journal-article","created":{"date-parts":[[2012,2,21]],"date-time":"2012-02-21T08:40:41Z","timestamp":1329813641000},"page":"1472-1479","source":"Crossref","is-referenced-by-count":66,"title":["Clinical Efficacy of Subgingivally Delivered 1.2\u2010mg Simvastatin in the Treatment of Individuals With Class II Furcation Defects: A Randomized Controlled Clinical 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