{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:38:39Z","timestamp":1791171519539,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Simvastatin (SMV) is a specific competitive inhibitor of 3\u2010hydroxy\u20102\u2010methyl\u2010glutaryl coenzyme A reductase. Recently, it has been reported that statins promote bone formation. The present study is designed to investigate the effectiveness of 1.2% SMV in an indigenously prepared, biodegradable, controlled\u2010release gel as an adjunct to scaling and root planing (SRP) in the treatment of patients with type 2 diabetes and chronic periodontitis (CP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010eight patients were categorized into two treatment groups: SRP plus 1.2% SMV and SRP plus placebo. Clinical parameters were recorded at baseline before SRP and at 3, 6, and 9 months; they included modified sulcus bleeding index (mSBI), probing depth (PD), and clinical attachment level (CAL). At baseline and after 6 and 9 months, radiologic assessment of intrabony defect (IBD) fill was done using computer\u2010aided software.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Mean PD reduction and mean CAL gain were found to be greater in the SMV group than the placebo group at 3, 6, and 9 months. Furthermore, significantly greater mean percentage of bone fill was found in the SMV group (32.64% \u00b1 12.90%) compared to the placebo group (4.22% \u00b1 9.75%) after 9 months.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> There was a greater decrease in mSBI and PD and more CAL gain with significant IBD fill at sites treated with SRP plus locally delivered SMV in patients with type 2 diabetes and CP.<\/jats:p>","DOI":"10.1902\/jop.2012.110721","type":"journal-article","created":{"date-parts":[[2012,3,16]],"date-time":"2012-03-16T04:55:42Z","timestamp":1331873742000},"page":"24-31","source":"Crossref","is-referenced-by-count":63,"title":["Efficacy of Subgingivally Delivered Simvastatin in the Treatment of Patients With Type 2 Diabetes and Chronic Periodontitis: A Randomized Double\u2010Masked Controlled Clinical 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