{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:11:53Z","timestamp":1774077113231,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p><jats:bold>Background<\/jats:bold><jats:bold>:<\/jats:bold> Peripheral arterial disease (PAD) is an important cardiovascular disorder of the peripheral arteries. Chronic infections, such as periodontitis, may play an important role in the etiology and pathophysiology of PAD and other cardiovascular conditions. Recently, <jats:italic>Streptococcus mutans<\/jats:italic> has been found with high frequency in atheromatous plaques. The aim of this study is to evaluate the possible clinical and microbiologic association between PAD and periodontitis and dental caries.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty patients with PAD and 30 control individuals were selected. PAD and its severity were established by the use of the ankle\u2010branchial index (ABI). Clinical attachment loss (AL); probing depth; decayed, missing, and filled teeth (DMFT) index; and C\u2010reactive protein (CRP) levels were evaluated. The presence of bacterial DNA from <jats:italic>Streptococcus mutans<\/jats:italic>, <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Tannerella forsythia<\/jats:italic>, <jats:italic>Prevotella intermedia<\/jats:italic>, <jats:italic>Treponema denticola<\/jats:italic>, and <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> was identified by polymerase chain reaction in subgingival biofilm and serum.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Patients with \u226530% AL \u2265 4 mm had six\u2010fold increased risk of having PAD (odds ratio = 8.18; 95% confidence interval = 1.21 to 35.23; <jats:italic>P<\/jats:italic> = 0.031). There was statistical difference in the CRP (<jats:italic>P<\/jats:italic> = 0.0413) and DMFT index (<jats:italic>P<\/jats:italic> = 0.0002), with elevated number of missing teeth (<jats:italic>P<\/jats:italic> = 0.0459) in the PAD group compared with the control group. There were no significant differences in the frequency of bacteria in serum and subgingival plaque.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> There was a positive relationship between periodontitis based on AL and PAD determined by the ABI (odds ratio = 8.18).<\/jats:p>","DOI":"10.1902\/jop.2012.120051","type":"journal-article","created":{"date-parts":[[2012,6,10]],"date-time":"2012-06-10T05:39:08Z","timestamp":1339306748000},"page":"486-494","source":"Crossref","is-referenced-by-count":44,"title":["Peripheral Arterial Disease Associated With Caries and Periodontal Disease"],"prefix":"10.1002","volume":"84","author":[{"given":"Uriel","family":"Soto\u2010Barreras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier O.","family":"Olvera\u2010Rubio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan P.","family":"Loyola\u2010Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F.","family":"Reyes\u2010Macias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita E.","family":"Martinez\u2010Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Pati\u00f1o\u2010Marin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel A.","family":"Martinez\u2010Casta\u00f1on","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"Aradillas\u2010Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James W.","family":"Little","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1971","article-title":"Peripheral vascular disease: Diagnosis and treatment","volume":"73","author":"Sontheimer DL","year":"2006","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.07.095"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.11.1317"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.1997.012004209.x"},{"key":"e_1_2_7_6_1","first-page":"1259","article-title":"Low rates of preventive practices in patients with peripheral vascular disease","volume":"15","author":"Anand SS","year":"1999","journal-title":"Can J Cardiol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000137913.26087.F0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004050409"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2481"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X9701700107"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0902.104353"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500606"},{"key":"e_1_2_7_13_1","first-page":"430","article-title":"Strength of evidence relating periodontal disease and atherosclerotic disease","volume":"30","author":"Joshipura K","year":"2009","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1554"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(98)00158-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.12.037"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2007.08.016"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000078603.90302.4A"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0300-9475.2004.01511.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060345"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02953.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00377-06"},{"key":"e_1_2_7_23_1","unstructured":"GrissomCK LuksAM DelougheryTG. 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