{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:32:06Z","timestamp":1790188326155,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> In this study, we compare the effectiveness of enamel matrix derivative (EMD) associated with a simplified papilla preservation flap (SPPF) technique to SPPF alone when surgically treating supra\u2010alveolar\u2010type defects.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Fifty patients, from 54 initially selected, presenting horizontal bone loss around \u22654 adjacent teeth, were treated by an SPPF technique; 25 participants also received EMD (test group) and 25 patients underwent flap surgery alone (control group). A complete clinical and radiographic examination was performed at baseline and 12 months after treatment. Pre\u2010 and post\u2010therapy probing depth (PD), clinical attachment level (CAL), gingival recession (GR), and radiographic bone level (BL) were compared between treatments.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> After 12 months, PD, CAL, and GR in both groups showed significant differences from baseline (<jats:italic>P<\/jats:italic> &lt;0.001). No differences in BL scores were observed within the groups at the 12\u2010month examination. After 1 year, the test group showed significantly (<jats:italic>P<\/jats:italic> &lt;0.001) greater PD reduction (3.4 \u00b1 0.7 mm) and CAL gain (2.8 \u00b1 0.8 mm) and a smaller GR increase (0.6 \u00b1 0.4 mm) compared to the control group (PD, 2.2 \u00b1 0.8 mm; CAL, 1.0 \u00b1 0.6 mm; GR, 1.2 \u00b1 0.7 mm.) BL changes did not significantly differ between the experimental groups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The results of this study suggest that combining EMD and SPPF in the treatment of suprabony defects may lead to a greater clinical improvement compared to SPPF alone.<\/jats:p>","DOI":"10.1902\/jop.2012.120075","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T13:10:31Z","timestamp":1349183431000},"page":"1100-1110","source":"Crossref","is-referenced-by-count":33,"title":["Treatment of Supra\u2010Alveolar\u2010Type Defects by a Simplified Papilla Preservation Technique for Access Flap Surgery With or Without Enamel Matrix Proteins"],"prefix":"10.1002","volume":"84","author":[{"given":"Marcella","family":"Di Tullio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Femminella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pilloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camillo","family":"D'Arcangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"De Ninis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Paolantonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2220106.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1982.53.1.8"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01369.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.1.102"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00253.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00248.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00247.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.3.341"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.5.752"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.1.25"},{"key":"e_1_2_7_12_1","first-page":"127","article-title":"A case report study of 72 consecutive Emdogain\u2010treated intrabony periodontal defects: Clinical and radiographic findings after 1 year","volume":"20","author":"Heden G","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.4.350"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00665.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb01122.x"},{"key":"e_1_2_7_16_1","first-page":"131","article-title":"Supracrestal bone regeneration: A pilot study","volume":"19","author":"Kassolis JD","year":"1999","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_17_1","first-page":"425","article-title":"Reconstruction of supracrestal alveolar bone lost as a result of severe chronic periodontitis. 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