{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:47:37Z","timestamp":1790228857623,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Recombinant human platelet\u2010derived growth factor (rhPDGF) is safe and effective for the treatment of periodontal defects in short\u2010term studies up to 6 months in duration. We now provide results from a 36\u2010month extension study of a multicenter, randomized, controlled clinical trial evaluating the effect and long\u2010term stability of PDGF\u2010BB treatment in patients with localized severe periodontal osseous defects.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 135 participants were enrolled from six clinical centers for an extension trial. Eighty\u2010three individuals completed the study at 36 months and were included in the analysis. The study investigated the local application of \u03b2\u2010tricalcium phosphate scaffold matrix with or without two different dose levels of PDGF (0.3 or 1.0 mg\/mL PDGF\u2010BB) in patients possessing one localized periodontal osseous defect. Composite analysis for clinical and radiographic evidence of treatment success was defined as percentage of cases with clinical attachment level (CAL) \u22652.7 mm and linear bone growth (LBG) \u22651.1 mm.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The participants exceeding this composite outcome benchmark in the 0.3 mg\/mL rhPDGF\u2010BB group went from 62.2% at 12 months, 75.9% at 24 months, to 87.0% at 36 months compared with 39.5%, 48.3%, and 53.8%, respectively, in the scaffold control group at these same time points (<jats:italic>P<\/jats:italic> &lt;0.05). Although there were no significant increases in CAL and LBG at 36 months among all groups, there were continued increases in CAL gain, LBG, and percentage bone fill over time, suggesting overall stability of the regenerative response.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> PDGF\u2010BB in a synthetic scaffold matrix promotes long\u2010term stable clinical and radiographic improvements as measured by composite outcomes for CAL gain and LBG for patients possessing localized periodontal defects (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> no. CT01530126).<\/jats:p>","DOI":"10.1902\/jop.2012.120141","type":"journal-article","created":{"date-parts":[[2012,5,21]],"date-time":"2012-05-21T16:10:03Z","timestamp":1337616603000},"page":"456-464","source":"Crossref","is-referenced-by-count":135,"title":["Platelet\u2010Derived Growth Factor Promotes Periodontal Regeneration in Localized Osseous Defects: 36\u2010Month Extension Results From a Randomized, Controlled, Double\u2010Masked Clinical Trial"],"prefix":"10.1002","volume":"84","author":[{"given":"Myron","family":"Nevins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela K.","family":"McClain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Hinrichs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley S.","family":"McAllister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc L.","family":"Nevins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Genco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel E.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William V.","family":"Giannobile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2011.554814"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.01231"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2002.0244"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb02334.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.12.1158"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1996.tb00497.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01639.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.9.1282"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2205"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.6.515"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.272.5.C1709"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.6.522"},{"key":"e_1_2_7_14_1","unstructured":"LynchSE. 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