{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:29:52Z","timestamp":1787023792575,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Several epidemiologic studies have identified a greater incidence of periodontitis in patients with type 2 diabetes. Recent developments suggest that local delivery of antimicrobials into periodontal pockets improve periodontal health. The present study is designed to investigate the adjunctive effects of subgingivally delivered azithromycin (AZM; 0.5% concentration) as an adjunct to scaling and root planing (SRP) for treating chronic periodontitis in patients with type 2 diabetes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    A total of 63 patients were categorized into two treatment groups: 1) group 1: SRP + placebo gel and 2) group 2: SRP + 0.5% AZM. Clinical parameters were recorded at baseline and 3, 6, and 9 months; they included modified sulcus bleeding index (mSBI), plaque index (PI), probing depth (PD), and clinical attachment level (CAL).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Both therapies resulted in significant improvements. Using a patient\u2010based analysis, patients in group 2 treated with SRP + 0.5% AZM showed enhanced reductions in PI, GI, mSBI, and PD and gains in CAL (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05) over 9 months compared with group 1.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Although both treatment strategies seem to benefit the patients, the adjunctive use of 0.5% AZM as a controlled drug delivery system enhances the clinical outcome.\n                  <\/jats:p>","DOI":"10.1902\/jop.2012.120172","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T11:50:41Z","timestamp":1338551441000},"page":"1281-1287","source":"Crossref","is-referenced-by-count":19,"title":["Locally Delivered 0.5% Azithromycin as an Adjunct to Non\u2010Surgical Treatment in Patients With Chronic Periodontitis With Type 2 Diabetes: A Randomized Controlled Clinical Trial"],"prefix":"10.1002","volume":"88","author":[{"given":"Esha","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savitha B.","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.R.","family":"Pradeep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","first-page":"11","article-title":"The etiology and pathogenesis of periodontitis","volume":"23","author":"Page RC","year":"2002","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00222.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1987.tb01595.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050459"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e3282f824b7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.2.123"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1990.0211"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2004.31.10.570"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00197.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.8s.760"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.7.393"},{"key":"e_1_2_8_13_1","first-page":"185","article-title":"Responsible use of antimicrobials in periodontics","volume":"28","author":"Jorgensen MG","year":"2000","journal-title":"J Calif Dent Assoc"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.11.1553"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.1998.tb00721.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01975835"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90394-D"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199244050-00007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.6.1241"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1993.tb00583.x"},{"key":"e_1_2_8_21_1","first-page":"290","article-title":"Antibiotic resistance in the subgingival microflora in patients with adult periodontitis. 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