{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:20:53Z","timestamp":1790000453994,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Rheumatoid arthritis (RA) and chronic periodontitis (CP) are the most common chronic inflammatory diseases and have remarkable similar pathologies. The aim of this study is to investigate the impact of periodontal status on oxidative stress in patients with RA by evaluating serum oxidative parameters and prolidase levels.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> For this cross\u2010sectional comparative study, the following four groups were composed of 20 individuals each (80 individuals total): 1) RA with CP (RA\u2010CP group); 2) RA but periodontally healthy (RA\u2010C group); 3) systemically healthy with CP (CP group); and 4) systemically and periodontally healthy (C group). Demographic, periodontal, rheumatological, and serum oxidative parameters as determined by serum total antioxidant status, total oxidant status, oxidative stress index (OSI), lipid hydroperoxide levels, paraoxonase, arylesterase, and ceruloplasmin activity, prolidase level, and total sulfhydryl groups were evaluated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The OSI values of the RA\u2010CP group were statistically significantly higher than those of the C group (<jats:italic>P<\/jats:italic> &lt;0.05). The prolidase levels of the RA\u2010C, RA\u2010CP groups and the CP group were statistically higher than those of the C group (<jats:italic>P<\/jats:italic> = 0.001, <jats:italic>P<\/jats:italic> = 0.007, and <jats:italic>P<\/jats:italic> = 0.001, respectively).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Although CP and RA each increase oxidative stress, in a small sample size these effects are only significant when both CP and RA are combined relative to neither exposure. In addition, increased prolidase levels in patients with RA and CP may be related to increased oxidative tissue damage.<\/jats:p>","DOI":"10.1902\/jop.2012.120179","type":"journal-article","created":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T00:04:13Z","timestamp":1342483453000},"page":"785-792","source":"Crossref","is-referenced-by-count":37,"title":["Effect of Chronic Periodontitis on Oxidative Status in Patients With Rheumatoid Arthritis"],"prefix":"10.1002","volume":"84","author":[{"given":"Ufuk","family":"Sezer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamile","family":"Erciyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemal","family":"\u00dcst\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yavuz","family":"Pehlivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcleyman","family":"Ziya \u015eenyurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurten","family":"Aksoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Tarak\u00e7\u0131o\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyithan","family":"Tays\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Mesut","family":"Onat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.4.457"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00760.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/215430"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.01060.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01122.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027004267.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072627"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00707-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-3084(97)00030-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110420"},{"key":"e_1_2_6_12_1","first-page":"467","article-title":"Evaluation of oxidative stress in rheumatoid and psoriatic arthritis and psoriasis","volume":"160","author":"Coaccioli S","year":"2009","journal-title":"Clin Ter"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2006.10.006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.08.003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.50.4.237"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.11.015"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.08.008"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.07.094"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.11.2313"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)00113-5"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(82)90196-6"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19971101)67:2<166::AID-JCB2>3.0.CO;2-V"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(88)90105-2"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e32830042ba"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_6_28_1","first-page":"257","article-title":"Antioxidant protection against hypochlorous acid in human plasma","volume":"121","author":"Hu ML","year":"1993","journal-title":"J Lab Clin Med"},{"key":"e_1_2_6_29_1","first-page":"391","article-title":"A new automated method for phenotyping arylesterase (EC 3.1.1.2) based upon inhibition of enzymatic hydrolysis of 4\u2010nitrophenyl acetate by phenyl acetate","volume":"30","author":"Haagen L","year":"1992","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"e_1_2_6_30_1","first-page":"1126","article-title":"The human serum paraoxonase\/arylesterase polymorphism","volume":"35","author":"Eckerson HW","year":"1983","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)44814-4"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.32"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.6.923"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070616"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.8s.828"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100173"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080218"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2009.01123.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01091.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0244-z"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1179\/135100010X12826446921707"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.20402"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2011.01630.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2004.00253.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-001-0163-x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0946-672X(00)80007-3"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-006-0300-8"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.06.010"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2008.01.029"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32182-9"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002960050097"},{"key":"e_1_2_6_53_1","first-page":"433","article-title":"Vitamin E, thiobarbituric acid reactive substance concentrations and superoxide dismutase activity in the blood of children with juvenile rheumatoid arthritis","volume":"14","author":"Sklodowska M","year":"1996","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_54_1","first-page":"1263","article-title":"Red blood cell susceptibility to lipid peroxidation, membrane lipid composition and antioxidant enzymes in patients with rheumatoid arthritis","volume":"18","author":"Olivieri O","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080447"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00689.x"},{"key":"e_1_2_6_57_1","article-title":"Protective effects of ginkgo biloba extract on ligature\u2010induced periodontitis in rats","author":"Sezer U","year":"2012","journal-title":"Acta Odontol Scand"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2010.01755.x"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2012.120179","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1902\/jop.2012.120179","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2012.120179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:41:20Z","timestamp":1760863280000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2012.120179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1902\/jop.2012.120179"],"URL":"https:\/\/doi.org\/10.1902\/jop.2012.120179","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}