{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:11:49Z","timestamp":1792656709596,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> In chronic periodontitis (CP), the gene polymorphism of interleukin\u20106 (IL\u20106) to 174C\/G has been associated with the altered production of this cytokine. The aim of this pilot study is to compare the allelic and genotypic frequencies in patients with CP with control individuals without periodontitis (NP) and to measure the production of IL\u20106 by whole blood cells stimulated with <jats:italic>Porphyromonas gingivalis<\/jats:italic> HmuY protein.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> DNA was isolated from peripheral blood cells of 49 patients with CP and 60 control individuals classified as NP, and genotyping was performed by polymerase chain reaction using sequence\u2010specific primers. Whole blood cells from 29 patients with CP and 30 control individuals were stimulated for 48 hours with HmuY, and IL\u20106 levels were measured using enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The proportion of individuals carrying the G allele at position \u2013174 of the IL\u20106 gene was higher in the group with CP (85.7%) than in the normal control group (73.3%; <jats:italic>P<\/jats:italic> &lt;0.03). <jats:italic>P. gingivalis<\/jats:italic> HmuY\u2010induced production of IL\u20106 was higher in the group with CP (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Our findings suggest that <jats:italic>P. gingivalis<\/jats:italic> HmuY may be associated with increased IL\u20106 production during CP. Furthermore, patients with periodontitis and individuals with higher HmuY\u2010induced production of IL\u20106 show a high frequency of the G allele at position \u2013174.<\/jats:p>","DOI":"10.1902\/jop.2012.120230","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T11:10:12Z","timestamp":1341573012000},"page":"650-655","source":"Crossref","is-referenced-by-count":26,"title":["<i>Porphyromonas gingivalis<\/i> HmuY\u2010Induced Production of Interleukin\u20106 and IL\u20106 Polymorphism in Chronic Periodontitis"],"prefix":"10.1002","volume":"84","author":[{"given":"Soraya Castro","family":"Trindade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Olczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac 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