{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:58:48Z","timestamp":1788872328939,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis Egyetem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    The purpose of the present study is to evaluate the 10\u2010year results following treatment of intrabony defects treated with an enamel matrix protein derivative (EMD) combined with either a natural bone mineral (NBM) or \u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Twenty\u2010two patients with advanced chronic periodontitis and displaying one deep intrabony defect were randomly treated with a combination of either EMD + NBM or EMD + \u03b2\u2010TCP. Clinical evaluations were performed at baseline and at 1 and 10 years. The following parameters were evaluated: plaque index, bleeding on probing, probing depth, gingival recession, and clinical attachment level (CAL). The primary outcome variable was CAL.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The defects treated with EMD + NBM demonstrated a mean CAL change from 8.9 \u00b1 1.5 mm to 5.3 \u00b1 0.9 mm (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001) and to 5.8 \u00b1 1.1 mm (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001) at 1 and 10 years, respectively. The sites treated with EMD + \u03b2\u2010TCP showed a mean CAL change from 9.1 \u00b1 1.6 mm to 5.4 \u00b1 1.1 mm (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001) at 1 year and 6.1 \u00b1 1.4 mm (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001) at 10 years. At 10 years two defects in the EMD + NBM group had lost 2 mm, whereas two other defects had lost 1 mm of the CAL gained at 1 year. In the EMD + \u03b2\u2010TCP group three defects had lost 2 mm, whereas two other defects had lost 1 mm of the CAL gained at 1 year. Compared with baseline, at 10 years, a CAL gain of \u22653 mm was measured in 64% (i.e., seven of 11) of the defects in the EMD + NBM group and in 82% (i.e., nine of 11) of the defects in the EMD + \u03b2\u2010TCP group. No statistically significant differences were found between the 1\u2010 and 10\u2010year values in either of the two groups. Between the treatment groups, no statistically significant differences in any of the investigated parameters were observed at 1 and 10 years.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Within their limitations, the present findings indicate that the clinical improvements obtained with regenerative surgery using EMD + NBM or EMD + \u03b2\u2010TCP can be maintained over a period of 10 years.\n                  <\/jats:p>","DOI":"10.1902\/jop.2012.120238","type":"journal-article","created":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T15:36:48Z","timestamp":1344440208000},"page":"749-757","source":"Crossref","is-referenced-by-count":46,"title":["Ten\u2010Year Results Following Treatment of Intrabony Defects With an Enamel Matrix Protein Derivative Combined With Either a Natural Bone Mineral or a \u03b2\u2010Tricalcium Phosphate"],"prefix":"10.1002","volume":"84","author":[{"given":"Ferenc","family":"D\u00f6ri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole 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