{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T23:37:55Z","timestamp":1773358675276,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Alpha lipoic acid (ALA) and vitamin C (Vit\u2010C) are very important and powerful antioxidants that have been used for the treatment of many diseases. The present study aims to investigate the role of ALA and Vit\u2010C substances in the treatment of alveolar bone resorption in periodontal diseases.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010six male Wistar albino rats were randomly divided into four groups as follows: 1) control rats; 2) rats with experimental periodontitis (PED); 3) rats with PED treated with ALA (ALA); and 4) rats with PED treated with ALA+Vit\u2010C (ALA+Vit\u2010C). PED was simulated by placing ligatures around the neck of teeth for 5 weeks. After ligature removal, the PED group was given a single intragastric dose of 1 mL saline, and the ALA and ALA+Vit\u2010C groups were treated with an intragastric dose of 50 mg\/kg ALA and ALA+Vit\u2010C for 15 days, respectively. Levels of serum bone alkaline phosphatase (B\u2010ALP) and myeloperoxidase (MPO) activity in gingival tissues were analyzed. To evaluate the osteoclast activation, expression of activated receptor activator nuclear factor\u2010kappa B ligand (RANKL) and bone density index (BDI) were determined stereologically in the bone sections obtained from the mandibles of the rats.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The results showed statistically significant differences between the PED group and groups treated with antioxidant according to B\u2010ALP, MPO, RANKL, and BDI values (<jats:italic>P &lt;<\/jats:italic>0.05). ALA and ALA+Vit\u2010C treatments showed beneficial effects on the mesial\/distal periodontal bone support at the ligature\u2010induced periodontitis tooth areas.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> This study shows that ALA and Vit\u2010C treatment provides therapeutic effects on inhibition of alveolar bone resorption and periodontal tissue destruction.<\/jats:p>","DOI":"10.1902\/jop.2012.120252","type":"journal-article","created":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T23:36:13Z","timestamp":1339803373000},"page":"666-674","source":"Crossref","is-referenced-by-count":42,"title":["Therapeutic Effects of Alpha Lipoic Acid and Vitamin C on Alveolar Bone Resorption After Experimental Periodontitis in Rats: A Biochemical, Histochemical, and Stereologic Study"],"prefix":"10.1002","volume":"84","author":[{"given":"Sumeyra","family":"Akman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varol","family":"Canakci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adem","family":"Kara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ummuhan","family":"Tozoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taner","family":"Arabaci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lhan Metin","family":"Dagsuyu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.09.040"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0311300"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4680(00)00053-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510375830"},{"key":"e_1_2_6_6_1","first-page":"81","article-title":"Plasma and crevicular fluid antioxidant defense in periodontitis and health [Congress presentation]","author":"Brock G","year":"2002","journal-title":"J Dent Res"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67728-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260402.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00178.x"},{"key":"e_1_2_6_10_1","first-page":"176","article-title":"Determination of systemically & locally induced periodontal defects in rats","volume":"121","author":"Keles GG","year":"2005","journal-title":"Indian J Med Res"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080041"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.don.0000153839.74546.66"},{"key":"e_1_2_6_13_1","first-page":"333","article-title":"The effect of ascorbic acid supplementation on periodontal tissue ultrastructure in subjects with progressive periodontitis","volume":"52","author":"Aurer\u2010Kozelj J","year":"1982","journal-title":"Int J Vitam Nutr Res"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)00017-R"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043365387"},{"key":"e_1_2_6_16_1","first-page":"15","article-title":"The role of nutrition in the treatment of periodontal disease","volume":"69","author":"Muroff FI","year":"1979","journal-title":"Oral Health"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.8.1215"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690031201"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02652558"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715769409147509"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(96)00172-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700511"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2010.01703.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.01.009"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.09.002"},{"key":"e_1_2_6_26_1","first-page":"2165","volume":"78","author":"Sanbe T","year":"2007","journal-title":"Oral administration of vitamin C prevents alveolar bone resorption induced by high dietary cholesterol in rats"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(97)00280-3"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12506462"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.5152\/eajm.2010.20"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-012-9412-4"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2924"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-83242009000400017"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715769109105221"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.05995"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00643.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0193-5"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00551-2"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1999.0600"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(03)00036-6"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1997.tb00363.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100147"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1320251"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1987.tb01534.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.20.3.0367"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2012.120252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:51:09Z","timestamp":1760878269000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2012.120252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1902\/jop.2012.120252"],"URL":"https:\/\/doi.org\/10.1902\/jop.2012.120252","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}