{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:27:42Z","timestamp":1790112462428,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The study is designed to determine the effect on clinical variables, subgingival bacteria, and local immune response brought about by application of hyaluronan\u2010containing gels in early wound healing after scaling and root planing (SRP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In this randomized clinical study, data from 34 individuals with chronic periodontitis were evaluated after full\u2010mouth SRP. In the test group (n = 17), hyaluronan gels in two molecular weights were additionally applied during the first 2 weeks after SRP. The control group (n = 17) was treated with SRP only. Probing depth (PD) and clinical attachment level (CAL) were recorded at baseline and after 3 and 6 months, and subgingival plaque and sulcus fluid samples were taken for microbiologic and biochemical analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In both groups, PD and CAL were significantly reduced (<jats:italic>P<\/jats:italic> &lt;0.001). The changes in PD and the reduction of the number of pockets with PD \u22655 mm were significantly higher in the test group after 3 (<jats:italic>P<\/jats:italic> = 0.014 and 0.021) and 6 (<jats:italic>P<\/jats:italic> = 0.046 and 0.045) months. Six months after SRP, the counts of <jats:italic>Treponema denticola<\/jats:italic> were significantly reduced in both groups (both <jats:italic>P<\/jats:italic> = 0.043), as were those of <jats:italic>Campylobacter rectus<\/jats:italic> in the test group only (<jats:italic>P<\/jats:italic> = 0.028). <jats:italic>Prevotella intermedia<\/jats:italic> and <jats:italic>Porphyromonas gingivalis<\/jats:italic> increased in the control group.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The adjunctive application of hyaluronan may have positive effects on PD reduction and may prevent recolonization by periodontopathogens.<\/jats:p>","DOI":"10.1902\/jop.2012.120269","type":"journal-article","created":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T17:24:20Z","timestamp":1350926660000},"page":"941-949","source":"Crossref","is-referenced-by-count":77,"title":["Hyaluronic Acid as an Adjunct After Scaling and Root Planing: A Prospective Randomized Clinical Trial"],"prefix":"10.1002","volume":"84","author":[{"given":"Sigrun","family":"Eick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Renatus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Heinicke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan\u2010Ioan","family":"Stratul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Jentsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2009.08.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","unstructured":"Van der WeijdenGA TimmermanMF. 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