{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:28:23Z","timestamp":1788870503207,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["320030\u2010122089"],"award-info":[{"award-number":["320030\u2010122089"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : It has been suggested that prescription of amoxicillin plus metronidazole in the context of periodontal therapy should be limited to patients with specific microbiologic profiles, especially those testing positive for\n                    <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>\n                    . The main purpose of this analysis is to determine if patients positive for\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    with moderate to advanced periodontitis benefit specifically from amoxicillin plus metronidazole given as an adjunct to full\u2010mouth scaling and root planing.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : This is a double\u2010masked, placebo\u2010controlled, randomized longitudinal study including 41 participants who were positive for\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    and 41 participants who were negative for\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    . All 82 patients received full\u2010mouth periodontal debridement performed within 48 hours. Patients then received either systemic antibiotics (375 mg amoxicillin and 500 mg metronidazole, three times daily) or placebo for 7 days. The primary outcome variable was persistence of sites with a probing depth (PD) &gt;4 mm and bleeding on probing (BOP) at the 3\u2010month reevaluation. Using multilevel logistic regression, the effect of the antibiotics was analyzed according to the following factors (interaction effect):\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    \u2013positive or \u2013negative at baseline, sex, age, smoking, tooth being a molar, and interdental location.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : At reevaluation, participants in the test group had significantly fewer sites with a persisting PD &gt;4 mm and BOP than control patients (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01). Being\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    \u2013positive or \u2013negative did not change the effect of the antibiotics. Patients benefited from the antibiotics irrespective of sex, age, or smoking status. Molars benefited significantly more from the antibiotics than non\u2010molars (\n                    <jats:italic>P<\/jats:italic>\n                    for interaction effect = 0.03).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : Patients who were positive for\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    had no specific benefit from amoxicillin plus metronidazole. Sites on molars benefited significantly more from the antibiotics than non\u2010molar sites.\n                  <\/jats:p>","DOI":"10.1902\/jop.2012.120281","type":"journal-article","created":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T15:36:48Z","timestamp":1344440208000},"page":"715-724","source":"Crossref","is-referenced-by-count":51,"title":["Are There Specific Benefits of Amoxicillin Plus Metronidazole in\n                    <i>Aggregatibacter actinomycetemcomitans<\/i>\n                    \u2010Associated Periodontitis? 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