{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:17:55Z","timestamp":1760919475057,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["R13\u20102003\u2010013\u201004002\u20100"],"award-info":[{"award-number":["R13\u20102003\u2010013\u201004002\u20100"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The objective of this study is to compare a candidate \u03b2\u2010tricalcium phosphate (\u03b2\u2010TCP) carrier technology with the absorbable collagen sponge (ACS) benchmark to support recombinant human growth\/differentiation factor\u20105 (rhGDF\u20105)\u2013stimulated periodontal wound healing\/regeneration.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Routine, bilateral, critical\u2010size (5\u2010mm), 1\u2010wall, intrabony periodontal defects were surgically created in the mandibular premolar region in 10 beagle dogs. Five animals received rhGDF\u20105\/\u03b2\u2010TCP and five animals received rhGDF\u20105\/ACS, with a total of 20 \u03bcg rhGDF\u20105 per defect. The animals were euthanized for histologic and histometric analyses at 8 weeks postsurgery.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Both rhGDF\u20105\/ACS and rhGDF\u20105\/\u03b2\u2010TCP stimulated the formation of functionally oriented periodontal ligament, cellular mixed fiber cementum, and woven\/lamellar bone. Bone regeneration (height and area) was significantly greater for the rhGDF\u20105\/\u03b2\u2010TCP construct than for the rhGDF\u20105\/ACS (3.26 \u00b1 0.30 mm versus 2.22 \u00b1 0.82 mm, <jats:italic>P<\/jats:italic> &lt;0.01; and 10.45 \u00b1 2.26 mm<jats:sup>2<\/jats:sup> versus 5.62 \u00b1 2.39 mm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic> &lt;0.01, respectively). Cementum formation ranged from 3.83 \u00b1 0.73 mm to 3.03 \u00b1 1.18 mm without significant differences between groups. Root resorption\/ankylosis was not observed.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The \u03b2\u2010TCP carrier technology significantly enhanced rhGDF\u20105\u2013stimulated bone formation compared with the ACS benchmark in this discriminating periodontal defect model. The structural integrity of the \u03b2\u2010TCP carrier, preventing compression while providing a framework for bone ingrowth, may account for the observed results.<\/jats:p>","DOI":"10.1902\/jop.2012.120307","type":"journal-article","created":{"date-parts":[[2012,8,16]],"date-time":"2012-08-16T14:45:58Z","timestamp":1345128358000},"page":"812-820","source":"Crossref","is-referenced-by-count":19,"title":["Comparison Between a \u03b2\u2010Tricalcium Phosphate and an Absorbable Collagen Sponge Carrier Technology for rhGDF\u20105\u2013Stimulated Periodontal Wound Healing\/Regeneration"],"prefix":"10.1002","volume":"84","author":[{"given":"Young\u2010Taek","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf 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